| pubmed-article:19264877 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19264877 | lifeskim:mentions | umls-concept:C0014939 | lld:lifeskim |
| pubmed-article:19264877 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:19264877 | lifeskim:mentions | umls-concept:C0085862 | lld:lifeskim |
| pubmed-article:19264877 | lifeskim:mentions | umls-concept:C1299583 | lld:lifeskim |
| pubmed-article:19264877 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:19264877 | lifeskim:mentions | umls-concept:C1955321 | lld:lifeskim |
| pubmed-article:19264877 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:19264877 | lifeskim:mentions | umls-concept:C1608386 | lld:lifeskim |
| pubmed-article:19264877 | lifeskim:mentions | umls-concept:C1549571 | lld:lifeskim |
| pubmed-article:19264877 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19264877 | pubmed:dateCreated | 2009-5-21 | lld:pubmed |
| pubmed-article:19264877 | pubmed:abstractText | Estrogen receptor-alpha (ERalpha) plays a critical role in male reproductive tract development and fertility. To determine whether estrogen-dependent and -independent ERalpha mechanisms are involved in male fertility, we examined male estrogen nonresponsive ERalpha knock-in mice. These animals have a point mutation (G525L) in the ligand-binding domain of ERalpha that significantly reduces interaction with, and response to, endogenous estrogens but does not affect growth factor activation of ligand-independent ERalpha pathways. Surprisingly, we found that ligand-independent ERalpha signaling is essential for concentrating epididymal sperm via regulation of efferent ductule fluid reabsorption. In contrast, estrogen-dependent ERalpha signaling is required for germ cell viability, most likely through support of Sertoli cell function. By treating estrogen nonresponsive ERalpha knock-in (ENERKI) mice with the ERalpha selective synthetic agonist propyl pyrazole triol, which is able to bind and activate G525L ERalpha in vivo, we discovered male fertility required neonatal estrogen-mediated ERalpha signaling. Thus, our work indicates both estrogen-dependent and -independent pathways play separable roles in male murine reproductive tract development and that the role of ERalpha in human infertility should be examined more closely. | lld:pubmed |
| pubmed-article:19264877 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19264877 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:19264877 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19264877 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19264877 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:19264877 | pubmed:issn | 1945-7170 | lld:pubmed |
| pubmed-article:19264877 | pubmed:author | pubmed-author:GreeneGeoffre... | lld:pubmed |
| pubmed-article:19264877 | pubmed:author | pubmed-author:RichburgJohn... | lld:pubmed |
| pubmed-article:19264877 | pubmed:author | pubmed-author:SinkeviciusKe... | lld:pubmed |
| pubmed-article:19264877 | pubmed:author | pubmed-author:LotanTamara... | lld:pubmed |
| pubmed-article:19264877 | pubmed:author | pubmed-author:WoloszynKarol... | lld:pubmed |
| pubmed-article:19264877 | pubmed:author | pubmed-author:LaineMurielM | lld:pubmed |
| pubmed-article:19264877 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19264877 | pubmed:volume | 150 | lld:pubmed |
| pubmed-article:19264877 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19264877 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19264877 | pubmed:pagination | 2898-905 | lld:pubmed |
| pubmed-article:19264877 | pubmed:dateRevised | 2010-9-23 | lld:pubmed |
| pubmed-article:19264877 | pubmed:meshHeading | pubmed-meshheading:19264877... | lld:pubmed |
| pubmed-article:19264877 | pubmed:meshHeading | pubmed-meshheading:19264877... | lld:pubmed |
| pubmed-article:19264877 | pubmed:meshHeading | pubmed-meshheading:19264877... | lld:pubmed |
| pubmed-article:19264877 | pubmed:meshHeading | pubmed-meshheading:19264877... | lld:pubmed |
| pubmed-article:19264877 | pubmed:meshHeading | pubmed-meshheading:19264877... | lld:pubmed |
| pubmed-article:19264877 | pubmed:meshHeading | pubmed-meshheading:19264877... | lld:pubmed |
| pubmed-article:19264877 | pubmed:meshHeading | pubmed-meshheading:19264877... | lld:pubmed |
| pubmed-article:19264877 | pubmed:meshHeading | pubmed-meshheading:19264877... | lld:pubmed |
| pubmed-article:19264877 | pubmed:meshHeading | pubmed-meshheading:19264877... | lld:pubmed |
| pubmed-article:19264877 | pubmed:meshHeading | pubmed-meshheading:19264877... | lld:pubmed |
| pubmed-article:19264877 | pubmed:meshHeading | pubmed-meshheading:19264877... | lld:pubmed |
| pubmed-article:19264877 | pubmed:meshHeading | pubmed-meshheading:19264877... | lld:pubmed |
| pubmed-article:19264877 | pubmed:meshHeading | pubmed-meshheading:19264877... | lld:pubmed |
| pubmed-article:19264877 | pubmed:meshHeading | pubmed-meshheading:19264877... | lld:pubmed |
| pubmed-article:19264877 | pubmed:meshHeading | pubmed-meshheading:19264877... | lld:pubmed |
| pubmed-article:19264877 | pubmed:meshHeading | pubmed-meshheading:19264877... | lld:pubmed |
| pubmed-article:19264877 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19264877 | pubmed:articleTitle | Estrogen-dependent and -independent estrogen receptor-alpha signaling separately regulate male fertility. | lld:pubmed |
| pubmed-article:19264877 | pubmed:affiliation | The Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA. | lld:pubmed |
| pubmed-article:19264877 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19264877 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:19264877 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:13982 | entrezgene:pubmed | pubmed-article:19264877 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19264877 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19264877 | lld:pubmed |
