| pubmed-article:19250906 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19250906 | lifeskim:mentions | umls-concept:C0019647 | lld:lifeskim |
| pubmed-article:19250906 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:19250906 | lifeskim:mentions | umls-concept:C1166688 | lld:lifeskim |
| pubmed-article:19250906 | lifeskim:mentions | umls-concept:C0001752 | lld:lifeskim |
| pubmed-article:19250906 | lifeskim:mentions | umls-concept:C0036720 | lld:lifeskim |
| pubmed-article:19250906 | lifeskim:mentions | umls-concept:C0086168 | lld:lifeskim |
| pubmed-article:19250906 | lifeskim:mentions | umls-concept:C1419989 | lld:lifeskim |
| pubmed-article:19250906 | lifeskim:mentions | umls-concept:C1419994 | lld:lifeskim |
| pubmed-article:19250906 | lifeskim:mentions | umls-concept:C1148677 | lld:lifeskim |
| pubmed-article:19250906 | lifeskim:mentions | umls-concept:C0443264 | lld:lifeskim |
| pubmed-article:19250906 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19250906 | pubmed:dateCreated | 2009-3-2 | lld:pubmed |
| pubmed-article:19250906 | pubmed:abstractText | Histone H3 serine 10 phosphorylation is a hallmark of mitotic chromosomes, but its full function remains to be elucidated. We report here that two SR protein splicing factors, SRp20 and ASF/SF2, associate with interphase chromatin, are released from hyperphosphorylated mitotic chromosomes, but reassociate with chromatin late in M-phase. Inhibition of Aurora B kinase diminished histone H3 serine 10 phosphorylation and increased SRp20 and ASF/SF2 retention on mitotic chromosomes. Unexpectedly, we also found that HP1 proteins interact with ASF/SF2 in mitotic cells. Strikingly, siRNA-mediated knockdown of ASF/SF2 caused retention of HP1 proteins on mitotic chromatin. Finally, ASF/SF2-depleted cells released from a mitotic block displayed delayed G0/G1 entry, suggesting a functional consequence of these interactions. These findings underscore the evolving role of histone H3 phosphorylation and demonstrate a direct, functional, and histone-modification-regulated association of SRp20 and ASF/SF2 with chromatin. | lld:pubmed |
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| pubmed-article:19250906 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19250906 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19250906 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19250906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19250906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19250906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19250906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19250906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19250906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19250906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19250906 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19250906 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19250906 | pubmed:issn | 1097-4164 | lld:pubmed |
| pubmed-article:19250906 | pubmed:author | pubmed-author:MacfarlanTodd... | lld:pubmed |
| pubmed-article:19250906 | pubmed:author | pubmed-author:ChakravartiDe... | lld:pubmed |
| pubmed-article:19250906 | pubmed:author | pubmed-author:ManleyJames... | lld:pubmed |
| pubmed-article:19250906 | pubmed:author | pubmed-author:LoomisRebecca... | lld:pubmed |
| pubmed-article:19250906 | pubmed:author | pubmed-author:NaoeYoshinori... | lld:pubmed |
| pubmed-article:19250906 | pubmed:author | pubmed-author:ParkerJ... | lld:pubmed |
| pubmed-article:19250906 | pubmed:author | pubmed-author:BozovskyMatth... | lld:pubmed |
| pubmed-article:19250906 | pubmed:author | pubmed-author:SavicVeliborV | lld:pubmed |
| pubmed-article:19250906 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19250906 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:19250906 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:19250906 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19250906 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19250906 | pubmed:pagination | 450-61 | lld:pubmed |
| pubmed-article:19250906 | pubmed:dateRevised | 2011-10-26 | lld:pubmed |
| pubmed-article:19250906 | pubmed:meshHeading | pubmed-meshheading:19250906... | lld:pubmed |
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| pubmed-article:19250906 | pubmed:meshHeading | pubmed-meshheading:19250906... | lld:pubmed |
| pubmed-article:19250906 | pubmed:meshHeading | pubmed-meshheading:19250906... | lld:pubmed |
| pubmed-article:19250906 | pubmed:meshHeading | pubmed-meshheading:19250906... | lld:pubmed |
| pubmed-article:19250906 | pubmed:meshHeading | pubmed-meshheading:19250906... | lld:pubmed |
