| pubmed-article:19249119 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19249119 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:19249119 | lifeskim:mentions | umls-concept:C1705004 | lld:lifeskim |
| pubmed-article:19249119 | lifeskim:mentions | umls-concept:C0009447 | lld:lifeskim |
| pubmed-article:19249119 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:19249119 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:19249119 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:19249119 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19249119 | pubmed:dateCreated | 2009-10-26 | lld:pubmed |
| pubmed-article:19249119 | pubmed:abstractText | Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by severe reduction in serum IgG and IgA with normal or low number of B-cells. Interleukin (IL)-4 and IL-10 levels could be altered in CVID patients, while cytokine production could be affected with polymorphisms of gene promoter regions. The allele and genotype frequencies of IL-4 and IL-10 gene promoter polymorphic sites were investigated in 30 CVID patients in comparison with controls. IL-10 GA genotype was the most frequent genotype at position -1082 in CVID patients, whereas IL-10 AA genotype was significantly decreased in the patient group at the same position. For IL-4, TG (-1098) and TC (-33) genotypes were significantly overrepresented in CVID group, while frequencies of IL-4 TT (-1098) and CC (-33) were significantly decreased in the patient group. Frequency of IL-10 ACA and IL4 GCC haplotypes in CVID patients were significantly higher than controls, whilst frequency of IL-10 ACC and IL-4 TCC significantly decreased in the patient group. Considering low frequency of IL-10 ACC low producing haplotype, high production of IL-10 could be explained in CVID patients. High production of IL-4 could also be expected based on haplotypes frequencies of this cytokine gene polymorphisms. | lld:pubmed |
| pubmed-article:19249119 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19249119 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19249119 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19249119 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19249119 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19249119 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19249119 | pubmed:issn | 1878-3279 | lld:pubmed |
| pubmed-article:19249119 | pubmed:author | pubmed-author:Aghamohammadi... | lld:pubmed |
| pubmed-article:19249119 | pubmed:author | pubmed-author:RezaeiNimaN | lld:pubmed |
| pubmed-article:19249119 | pubmed:author | pubmed-author:MahmoudiMarya... | lld:pubmed |
| pubmed-article:19249119 | pubmed:author | pubmed-author:AmirzargarAli... | lld:pubmed |
| pubmed-article:19249119 | pubmed:author | pubmed-author:KardarGholam... | lld:pubmed |
| pubmed-article:19249119 | pubmed:author | pubmed-author:MoradiBatoulB | lld:pubmed |
| pubmed-article:19249119 | pubmed:author | pubmed-author:ShakibaYadoll... | lld:pubmed |
| pubmed-article:19249119 | pubmed:author | pubmed-author:MahmoudiMahdi... | lld:pubmed |
| pubmed-article:19249119 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19249119 | pubmed:volume | 215 | lld:pubmed |
| pubmed-article:19249119 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19249119 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19249119 | pubmed:pagination | 81-7 | lld:pubmed |
| pubmed-article:19249119 | pubmed:meshHeading | pubmed-meshheading:19249119... | lld:pubmed |
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| pubmed-article:19249119 | pubmed:meshHeading | pubmed-meshheading:19249119... | lld:pubmed |
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| pubmed-article:19249119 | pubmed:meshHeading | pubmed-meshheading:19249119... | lld:pubmed |
| pubmed-article:19249119 | pubmed:meshHeading | pubmed-meshheading:19249119... | lld:pubmed |
| pubmed-article:19249119 | pubmed:meshHeading | pubmed-meshheading:19249119... | lld:pubmed |
| pubmed-article:19249119 | pubmed:meshHeading | pubmed-meshheading:19249119... | lld:pubmed |
| pubmed-article:19249119 | pubmed:meshHeading | pubmed-meshheading:19249119... | lld:pubmed |
| pubmed-article:19249119 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:19249119 | pubmed:articleTitle | Association of IL-4 and IL-10 gene promoter polymorphisms with common variable immunodeficiency. | lld:pubmed |
| pubmed-article:19249119 | pubmed:affiliation | Immunology, Asthma and Allergy Research Institute, Children's Medical Center Hospital, Tehran University of Medical Sciences, Iran. rezaei_nima@hbi.ir | lld:pubmed |
| pubmed-article:19249119 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19249119 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3565 | entrezgene:pubmed | pubmed-article:19249119 | lld:entrezgene |
| entrez-gene:3586 | entrezgene:pubmed | pubmed-article:19249119 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19249119 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19249119 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19249119 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19249119 | lld:entrezgene |
