Linked Life Data

19246034

Source:http://linkedlifedata.com/resource/pubmed/id/19246034

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pubmed-article:19246034pubmed:abstractTextThe molecular action mechanism of MRP, one of the protein kinase C (PKC) substrates, has been under intense investigation, but reports on its role in macrophage function remain controversial. The treatment of macrophage cell lines with bacterial lipopolysaccharide (LPS) induced a high level of MRP expression suggesting that MRP plays a role in the function of activated macrophages. In order to investigate the role of MRP in activated RAW264.7 cells, we stably transfected MRP-specific shRNA expression constructs and tested for alterations in macrophage-related functions. The down-regulation of MRP expression resulted in a marked reduction in chemotaxis toward MCP-1 or extracellular matrix proteins. Furthermore, pharmacological inhibitors of PKC significantly inhibited the chemotaxis in RAW264.7 cells. These data reveals the pivotal role of MRP in the transmigration of activated RAW264.7 cells.lld:pubmed
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pubmed-article:19246034pubmed:year2009lld:pubmed
pubmed-article:19246034pubmed:articleTitleSuppression of the lipopolysaccharide-induced expression of MARCKS-related protein (MRP) affects transmigration in activated RAW264.7 cells.lld:pubmed
pubmed-article:19246034pubmed:affiliationDepartment of Genetic Engineering, Kyungpook National University, Daegu, Republic of Korea.lld:pubmed
pubmed-article:19246034pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19246034pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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