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pubmed-article:19239712pubmed:abstractTextNeonatal respiratory distress syndrome, as a consequence of preterm birth, is a major cause of early mortality and morbidity during infancy and childhood. Survivors of preterm birth continue to remain at considerable risk of both chronic lung disease and long-term neurological handicap. Progesterone is involved in the maintenance of uterine quiescence through modulation of the calcium-calmodulin-myosin-light-chain-kinase system in smooth muscle cells. The withdrawal of progesterone, either actual or functional is thought to be an antecedent to the onset of labour. While there have been recent reports of progesterone supplementation for women at risk of preterm birth which show promise in this intervention, there is currently insufficient data on clinically important outcomes for both women and infants to enable informed clinical decision-making. The aims of this randomised, double blind, placebo controlled trial are to assess whether the use of vaginal progesterone pessaries in women with a history of previous spontaneous preterm birth will reduce the risk and severity of respiratory distress syndrome, so improving their infant's health, without increasing maternal risks.lld:pubmed
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pubmed-article:19239712pubmed:authorpubmed-author:DoddJodie MJMlld:pubmed
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pubmed-article:19239712pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:19239712pubmed:articleTitleProgesterone after previous preterm birth for prevention of neonatal respiratory distress syndrome (PROGRESS): a randomised controlled trial.lld:pubmed
pubmed-article:19239712pubmed:affiliationDiscipline of Obstetrics and Gynaecology, The University of Adelaide, Adelaide, SA, Australia. jodie.dodd@adelaide.edu.aulld:pubmed
pubmed-article:19239712pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19239712pubmed:publicationTypeRandomized Controlled Triallld:pubmed
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