| pubmed-article:19238311 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19238311 | lifeskim:mentions | umls-concept:C1801960 | lld:lifeskim |
| pubmed-article:19238311 | lifeskim:mentions | umls-concept:C0011884 | lld:lifeskim |
| pubmed-article:19238311 | lifeskim:mentions | umls-concept:C0540511 | lld:lifeskim |
| pubmed-article:19238311 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:19238311 | lifeskim:mentions | umls-concept:C0020456 | lld:lifeskim |
| pubmed-article:19238311 | lifeskim:mentions | umls-concept:C0035331 | lld:lifeskim |
| pubmed-article:19238311 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:19238311 | lifeskim:mentions | umls-concept:C1176299 | lld:lifeskim |
| pubmed-article:19238311 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19238311 | pubmed:dateCreated | 2010-2-4 | lld:pubmed |
| pubmed-article:19238311 | pubmed:abstractText | Our previous data suggested that angiopoietin-2 (Ang-2) is linked to pericyte loss, thereby playing an important role in diabetic retinopathy. In this study, we investigated the effect of retinal overexpression of human Ang-2 (mOpsinhAng2 mouse) on vascular morphology in non-diabetic and streptozotozin-induced diabetic animals. Pericyte (PC) coverage and acellular capillary (AC) formation were quantitated in retinal digest preparations after 3 and 6 months of diabetes duration. The degree of retinopathy in non-diabetic mOpsinhAng2 mice at 3 months (-21% PC, +49% AC) was comparable to age-matched diabetic wild type mice. Diabetic mOpsinhAng2 mice exhibited significantly worse vascular pathology than wild type counterparts at 6 months. Quantitative PCR revealed that human Ang-2 mRNA was highly overexpressed in retinas of transgenic mice. Our data demonstrate that overexpression of Ang-2 in the retina enhances vascular pathology, indicating that Ang-2 plays an essential role in diabetic vasoregression via destabilization of pericytes. | lld:pubmed |
| pubmed-article:19238311 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19238311 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19238311 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19238311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19238311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19238311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19238311 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19238311 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:19238311 | pubmed:issn | 1432-5233 | lld:pubmed |
| pubmed-article:19238311 | pubmed:author | pubmed-author:WangYumeiY | lld:pubmed |
| pubmed-article:19238311 | pubmed:author | pubmed-author:SchreiterKayK | lld:pubmed |
| pubmed-article:19238311 | pubmed:author | pubmed-author:HammesHans-Pe... | lld:pubmed |
| pubmed-article:19238311 | pubmed:author | pubmed-author:FengYuxiY | lld:pubmed |
| pubmed-article:19238311 | pubmed:author | pubmed-author:HoffmannSigri... | lld:pubmed |
| pubmed-article:19238311 | pubmed:author | pubmed-author:DeutschUrbanU | lld:pubmed |
| pubmed-article:19238311 | pubmed:author | pubmed-author:vom... | lld:pubmed |
| pubmed-article:19238311 | pubmed:author | pubmed-author:PfisterFreder... | lld:pubmed |
| pubmed-article:19238311 | pubmed:author | pubmed-author:AltvaterKarin... | lld:pubmed |
| pubmed-article:19238311 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19238311 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:19238311 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19238311 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19238311 | pubmed:pagination | 59-64 | lld:pubmed |
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| pubmed-article:19238311 | pubmed:meshHeading | pubmed-meshheading:19238311... | lld:pubmed |
| pubmed-article:19238311 | pubmed:meshHeading | pubmed-meshheading:19238311... | lld:pubmed |
| pubmed-article:19238311 | pubmed:meshHeading | pubmed-meshheading:19238311... | lld:pubmed |
| pubmed-article:19238311 | pubmed:meshHeading | pubmed-meshheading:19238311... | lld:pubmed |
| pubmed-article:19238311 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:19238311 | pubmed:articleTitle | Retinal overexpression of angiopoietin-2 mimics diabetic retinopathy and enhances vascular damages in hyperglycemia. | lld:pubmed |
| pubmed-article:19238311 | pubmed:affiliation | 5th Medical Clinic, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. | lld:pubmed |
| pubmed-article:19238311 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19238311 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
