| pubmed-article:19234171 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19234171 | lifeskim:mentions | umls-concept:C0029341 | lld:lifeskim |
| pubmed-article:19234171 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:19234171 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:19234171 | lifeskim:mentions | umls-concept:C0011065 | lld:lifeskim |
| pubmed-article:19234171 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:19234171 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:19234171 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:19234171 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:19234171 | lifeskim:mentions | umls-concept:C1546956 | lld:lifeskim |
| pubmed-article:19234171 | lifeskim:mentions | umls-concept:C1441547 | lld:lifeskim |
| pubmed-article:19234171 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:19234171 | lifeskim:mentions | umls-concept:C0449450 | lld:lifeskim |
| pubmed-article:19234171 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:19234171 | pubmed:dateCreated | 2009-2-23 | lld:pubmed |
| pubmed-article:19234171 | pubmed:abstractText | During viral infection, dendritic cells (DCs) capture infected cells and present viral Ags to CD8(+) T cells. However, activated DCs might potentially present cell-associated Ags derived from captured dead cells. In this study, we find that human DCs that captured dead cells containing the TLR3 agonist poly(I:C) produced cytokines and underwent maturation, but failed to elicit autologous CD8(+) T cell responses against Ags of dead cells. Accordingly, DCs that captured dead cells containing poly(I:C), or influenza virus, are unable to activate CD8(+) T cell clones specific to cell-associated Ags of captured dead cells. CD4(+) T cells are expanded with DCs that have captured poly(I:C)-containing dead cells, indicating the inhibition is specific for MHC class I-restricted cross-presentation. Furthermore, these DCs can expand naive allogeneic CD8(+) T cells. Finally, soluble or targeted Ag is presented when coloaded onto DCs that have captured poly(I:C)-containing dead cells, indicating the inhibition is specific for dead cell cargo that is accompanied by viral or poly(I:C) stimulus. Thus, DCs have a mechanism that prevents MHC class I-restricted cross-presentation of cell-associated Ag when they have captured dead infected cells. | lld:pubmed |
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| pubmed-article:19234171 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19234171 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19234171 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:19234171 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19234171 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19234171 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:19234171 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:19234171 | pubmed:author | pubmed-author:ZurawskiGerar... | lld:pubmed |
