| pubmed-article:19231178 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19231178 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:19231178 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:19231178 | lifeskim:mentions | umls-concept:C0030193 | lld:lifeskim |
| pubmed-article:19231178 | lifeskim:mentions | umls-concept:C0268563 | lld:lifeskim |
| pubmed-article:19231178 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:19231178 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:19231178 | lifeskim:mentions | umls-concept:C1554184 | lld:lifeskim |
| pubmed-article:19231178 | lifeskim:mentions | umls-concept:C1880355 | lld:lifeskim |
| pubmed-article:19231178 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:19231178 | lifeskim:mentions | umls-concept:C0596431 | lld:lifeskim |
| pubmed-article:19231178 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19231178 | pubmed:dateCreated | 2009-3-9 | lld:pubmed |
| pubmed-article:19231178 | pubmed:abstractText | The purinoceptor subtypes P2X(3) and P2X(2/3) have been shown to play a pivotal role in models of various pain conditions. Identification of a potent and selective dual P2X(3)/P2X(2/3) diaminopyrimidine antagonist RO-4 prompted subsequent optimization of the template. This paper describes the SAR and optimization of the diaminopyrimidine ring and particularly the substitution of the 2-amino group. The discovery of the highly potent and drug-like dual P2X(3)/P2X(2/3) antagonist RO-51 is presented. | lld:pubmed |
| pubmed-article:19231178 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19231178 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19231178 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19231178 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19231178 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19231178 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19231178 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19231178 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19231178 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19231178 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:19231178 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:19231178 | pubmed:author | pubmed-author:FordAnthony... | lld:pubmed |
| pubmed-article:19231178 | pubmed:author | pubmed-author:DillonMichael... | lld:pubmed |
| pubmed-article:19231178 | pubmed:author | pubmed-author:JahangirAlamA | lld:pubmed |
| pubmed-article:19231178 | pubmed:author | pubmed-author:AlamMuzaffarM | lld:pubmed |
| pubmed-article:19231178 | pubmed:author | pubmed-author:LinClaraC | lld:pubmed |
| pubmed-article:19231178 | pubmed:author | pubmed-author:GeverJoel RJR | lld:pubmed |
| pubmed-article:19231178 | pubmed:author | pubmed-author:CarterDavid... | lld:pubmed |
| pubmed-article:19231178 | pubmed:author | pubmed-author:ZhaiYanshengY | lld:pubmed |
| pubmed-article:19231178 | pubmed:author | pubmed-author:BoisDaisy... | lld:pubmed |
| pubmed-article:19231178 | pubmed:author | pubmed-author:WagnerPaul... | lld:pubmed |
| pubmed-article:19231178 | pubmed:author | pubmed-author:ZiraJeffJ | lld:pubmed |
| pubmed-article:19231178 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19231178 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:19231178 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:19231178 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19231178 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19231178 | pubmed:pagination | 1632-5 | lld:pubmed |
| pubmed-article:19231178 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:19231178 | pubmed:meshHeading | pubmed-meshheading:19231178... | lld:pubmed |
| pubmed-article:19231178 | pubmed:meshHeading | pubmed-meshheading:19231178... | lld:pubmed |
| pubmed-article:19231178 | pubmed:meshHeading | pubmed-meshheading:19231178... | lld:pubmed |
| pubmed-article:19231178 | pubmed:meshHeading | pubmed-meshheading:19231178... | lld:pubmed |
| pubmed-article:19231178 | pubmed:meshHeading | pubmed-meshheading:19231178... | lld:pubmed |
| pubmed-article:19231178 | pubmed:meshHeading | pubmed-meshheading:19231178... | lld:pubmed |
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| pubmed-article:19231178 | pubmed:meshHeading | pubmed-meshheading:19231178... | lld:pubmed |
| pubmed-article:19231178 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19231178 | pubmed:articleTitle | Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X(3)/P2X(2/3) antagonist for the treatment of pain. | lld:pubmed |
| pubmed-article:19231178 | pubmed:affiliation | Department of Medicinal Chemistry, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, CA 94304, USA. | lld:pubmed |
| pubmed-article:19231178 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:19231178 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19231178 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19231178 | lld:pubmed |
