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pubmed-article:19228743pubmed:abstractTextThis was a phase I trial to determine the maximum tolerated dose and toxicity of deforolimus (AP23573, MK-8669), an inhibitor of mammalian target of rapamycin (mTOR). The pharmacokinetics, pharmacodynamics, and antineoplastic effects were also studied.lld:pubmed
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pubmed-article:19228743pubmed:articleTitleA phase I trial to determine the safety, tolerability, and maximum tolerated dose of deforolimus in patients with advanced malignancies.lld:pubmed
pubmed-article:19228743pubmed:affiliationDepartment of Pediatrics, Cancer Research Center, and Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago, Chicago, Illinois 60637, USA.lld:pubmed
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