| pubmed-article:19225820 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19225820 | lifeskim:mentions | umls-concept:C0599050 | lld:lifeskim |
| pubmed-article:19225820 | lifeskim:mentions | umls-concept:C1003433 | lld:lifeskim |
| pubmed-article:19225820 | lifeskim:mentions | umls-concept:C0327921 | lld:lifeskim |
| pubmed-article:19225820 | lifeskim:mentions | umls-concept:C0205112 | lld:lifeskim |
| pubmed-article:19225820 | lifeskim:mentions | umls-concept:C0332597 | lld:lifeskim |
| pubmed-article:19225820 | lifeskim:mentions | umls-concept:C1704332 | lld:lifeskim |
| pubmed-article:19225820 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19225820 | pubmed:dateCreated | 2009-4-24 | lld:pubmed |
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| pubmed-article:19225820 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19225820 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19225820 | pubmed:abstractText | Large-scale--even genome-wide--duplications have repeatedly been invoked as an explanation for major radiations. Teleosts, the most species-rich vertebrate clade, underwent a "fish-specific genome duplication" (FSGD) that is shared by most ray-finned fish lineages. We investigate here the Hox complement of the goldeye (Hiodon alosoides), a representative of Osteoglossomorpha, the most basal teleostean clade. An extensive PCR survey reveals that goldeye has at least eight Hox clusters, indicating a duplicated genome compared to basal actinopterygians. The possession of duplicated Hox clusters is uncoupled to species richness. The Hox system of the goldeye is substantially different from that of other teleost lineages, having retained several duplicates of Hox genes for which crown teleosts have lost at least one copy. A detailed analysis of the PCR fragments as well as full length sequences of two HoxA13 paralogs, and HoxA10 and HoxC4 genes places the duplication event close in time to the divergence of Osteoglossomorpha and crown teleosts. The data are consistent with-but do not conclusively prove-that Osteoglossomorpha shares the FSGD. | lld:pubmed |
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