| pubmed-article:1922386 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1922386 | lifeskim:mentions | umls-concept:C0068355 | lld:lifeskim |
| pubmed-article:1922386 | lifeskim:mentions | umls-concept:C0086376 | lld:lifeskim |
| pubmed-article:1922386 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:1922386 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:1922386 | pubmed:issue | 6345 | lld:pubmed |
| pubmed-article:1922386 | pubmed:dateCreated | 1991-11-21 | lld:pubmed |
| pubmed-article:1922386 | pubmed:abstractText | Professional phagocytes, such as neutrophils and monocytes, have an NADPH oxidase that generates superoxide and other reduced oxygen species important in killing microorganisms. Several components of the oxidase complex have been identified as targets of genetic defects causing chronic granulomatous disease. The complex consists of an electron transport chain that has as its substrate cytosolic NADPH and which discharges superoxide into the cavity of the intracellular phagocytic vacuole. The only electron transport component identified so far is a low-potential cytochrome b, apparently the only membrane component required. At least three cytosolic factors are also necessary, two of which, p67phOx and p47phOx, have been identified by their absence in patients with chronic granulomatous disease. A third component, sigma 1, is required for stimulation of oxidase activity in a cell-free system. The active components of purified sigma 1 are two proteins that associate as heterodimers, and here we report that these are the small GTP-binding protein p21rac1 and the GDP-dissociation inhibitor rhoGDI. | lld:pubmed |
| pubmed-article:1922386 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1922386 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1922386 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1922386 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1922386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1922386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1922386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1922386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1922386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1922386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1922386 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1922386 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1922386 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:1922386 | pubmed:author | pubmed-author:AbeKK | lld:pubmed |
| pubmed-article:1922386 | pubmed:author | pubmed-author:PickEE | lld:pubmed |
| pubmed-article:1922386 | pubmed:author | pubmed-author:SegalA WAW | lld:pubmed |
| pubmed-article:1922386 | pubmed:author | pubmed-author:HallAA | lld:pubmed |
| pubmed-article:1922386 | pubmed:author | pubmed-author:TeahanC GCG | lld:pubmed |
| pubmed-article:1922386 | pubmed:author | pubmed-author:TottyNN | lld:pubmed |
| pubmed-article:1922386 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1922386 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:1922386 | pubmed:volume | 353 | lld:pubmed |
| pubmed-article:1922386 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1922386 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1922386 | pubmed:pagination | 668-70 | lld:pubmed |
| pubmed-article:1922386 | pubmed:dateRevised | 2009-9-29 | lld:pubmed |
| pubmed-article:1922386 | pubmed:meshHeading | pubmed-meshheading:1922386-... | lld:pubmed |
| pubmed-article:1922386 | pubmed:meshHeading | pubmed-meshheading:1922386-... | lld:pubmed |
| pubmed-article:1922386 | pubmed:meshHeading | pubmed-meshheading:1922386-... | lld:pubmed |
| pubmed-article:1922386 | pubmed:meshHeading | pubmed-meshheading:1922386-... | lld:pubmed |
| pubmed-article:1922386 | pubmed:meshHeading | pubmed-meshheading:1922386-... | lld:pubmed |
| pubmed-article:1922386 | pubmed:meshHeading | pubmed-meshheading:1922386-... | lld:pubmed |
| pubmed-article:1922386 | pubmed:meshHeading | pubmed-meshheading:1922386-... | lld:pubmed |
| pubmed-article:1922386 | pubmed:meshHeading | pubmed-meshheading:1922386-... | lld:pubmed |
| pubmed-article:1922386 | pubmed:meshHeading | pubmed-meshheading:1922386-... | lld:pubmed |
| pubmed-article:1922386 | pubmed:meshHeading | pubmed-meshheading:1922386-... | lld:pubmed |
| pubmed-article:1922386 | pubmed:meshHeading | pubmed-meshheading:1922386-... | lld:pubmed |
| pubmed-article:1922386 | pubmed:meshHeading | pubmed-meshheading:1922386-... | lld:pubmed |
| pubmed-article:1922386 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1922386 | pubmed:articleTitle | Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1. | lld:pubmed |
| pubmed-article:1922386 | pubmed:affiliation | Laboratory of Immunopharmacology, Sackler School of Medicine, Tel Aviv University, Israel. | lld:pubmed |
| pubmed-article:1922386 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1922386 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1922386 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:1922386 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1922386 | lld:pubmed |
