| pubmed-article:19222999 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19222999 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:19222999 | lifeskim:mentions | umls-concept:C1414630 | lld:lifeskim |
| pubmed-article:19222999 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:19222999 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:19222999 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19222999 | pubmed:dateCreated | 2009-3-16 | lld:pubmed |
| pubmed-article:19222999 | pubmed:abstractText | The small G-protein Rheb regulates cell growth via the mTORC1 complex by incompletely understood mechanisms. Recent studies document that Rheb activates mTORC1 via direct, GTP-dependent interaction with the peptidyl-prolyl-cis/trans-isomerase FKBP38, which is proposed to act as an inhibitor of mTORC1. We have conducted a comprehensive biochemical characterization of the Rheb/FKBP38 interaction. Using three different in vitro assays we did not detect an interaction between Rheb and FKBP38. Cell biological experiments illustrate that FKBP38 plays only a very minor, if any, role in mTORC1 activation. Our data document that FKBP38 is not the long-sought Rheb effector linking Rheb to mTORC1 activation. | lld:pubmed |
| pubmed-article:19222999 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19222999 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19222999 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19222999 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19222999 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:19222999 | pubmed:issn | 1873-3468 | lld:pubmed |
| pubmed-article:19222999 | pubmed:author | pubmed-author:WittinghoferA... | lld:pubmed |
| pubmed-article:19222999 | pubmed:author | pubmed-author:WetzkerReinha... | lld:pubmed |
| pubmed-article:19222999 | pubmed:author | pubmed-author:FischerGunter... | lld:pubmed |
| pubmed-article:19222999 | pubmed:author | pubmed-author:RubioIgnacioI | lld:pubmed |
| pubmed-article:19222999 | pubmed:author | pubmed-author:WeiwadMatthia... | lld:pubmed |
| pubmed-article:19222999 | pubmed:author | pubmed-author:UhlenbrockKat... | lld:pubmed |
| pubmed-article:19222999 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19222999 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:19222999 | pubmed:volume | 583 | lld:pubmed |
| pubmed-article:19222999 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19222999 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19222999 | pubmed:pagination | 965-70 | lld:pubmed |
| pubmed-article:19222999 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:19222999 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19222999 | pubmed:articleTitle | Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway. | lld:pubmed |
| pubmed-article:19222999 | pubmed:affiliation | Department of Structural Biology, Max Planck Institute for Molecular Physiology, Dortmund, Germany. | lld:pubmed |
| pubmed-article:19222999 | pubmed:publicationType | Journal Article | lld:pubmed |
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