Linked Life Data

19217150

Source:http://linkedlifedata.com/resource/pubmed/id/19217150

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:19217150rdf:typepubmed:Citationlld:pubmed
pubmed-article:19217150lifeskim:mentionsumls-concept:C0019425lld:lifeskim
pubmed-article:19217150lifeskim:mentionsumls-concept:C0014257lld:lifeskim
pubmed-article:19217150lifeskim:mentionsumls-concept:C0027627lld:lifeskim
pubmed-article:19217150lifeskim:mentionsumls-concept:C1519687lld:lifeskim
pubmed-article:19217150lifeskim:mentionsumls-concept:C0011155lld:lifeskim
pubmed-article:19217150lifeskim:mentionsumls-concept:C1412925lld:lifeskim
pubmed-article:19217150lifeskim:mentionsumls-concept:C1882115lld:lifeskim
pubmed-article:19217150pubmed:issue5lld:pubmed
pubmed-article:19217150pubmed:dateCreated2009-3-9lld:pubmed
pubmed-article:19217150pubmed:abstractTextA key function of blood vessels, to supply oxygen, is impaired in tumors because of abnormalities in their endothelial lining. PHD proteins serve as oxygen sensors and may regulate oxygen delivery. We therefore studied the role of endothelial PHD2 in vessel shaping by implanting tumors in PHD2(+/-) mice. Haplodeficiency of PHD2 did not affect tumor vessel density or lumen size, but normalized the endothelial lining and vessel maturation. This resulted in improved tumor perfusion and oxygenation and inhibited tumor cell invasion, intravasation, and metastasis. Haplodeficiency of PHD2 redirected the specification of endothelial tip cells to a more quiescent cell type, lacking filopodia and arrayed in a phalanx formation. This transition relied on HIF-driven upregulation of (soluble) VEGFR-1 and VE-cadherin. Thus, decreased activity of an oxygen sensor in hypoxic conditions prompts endothelial cells to readjust their shape and phenotype to restore oxygen supply. Inhibition of PHD2 may offer alternative therapeutic opportunities for anticancer therapy.lld:pubmed
pubmed-article:19217150pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19217150pubmed:languageenglld:pubmed
pubmed-article:19217150pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19217150pubmed:citationSubsetIMlld:pubmed
pubmed-article:19217150pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19217150pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19217150pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19217150pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19217150pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19217150pubmed:statusMEDLINElld:pubmed
pubmed-article:19217150pubmed:monthMarlld:pubmed
pubmed-article:19217150pubmed:issn1097-4172lld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:AragonésJuliá...lld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:SimonsMichael...lld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:CarmelietPete...lld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:DebackereKoen...lld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:LuttunAernout...lld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:DejanaElisabe...lld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:SchmidtThomas...lld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:LogesSonjaSlld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:LampugnaniMar...lld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:MazzoneMassim...lld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:GallezBernard...lld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:TianYa-MinYMlld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:VinckierStefa...lld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:De...lld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:PisacaneAlber...lld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:RatcliffePete...lld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:WynsSabineSlld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:JonckxBartBlld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:MaxwellPatric...lld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:LanahanAnthon...lld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:PollardPatric...lld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:Ruiz de...lld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:DettoriDaniel...lld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:JordanBenedic...lld:pubmed
pubmed-article:19217150pubmed:authorpubmed-author:Leite de...lld:pubmed
pubmed-article:19217150pubmed:issnTypeElectroniclld:pubmed
pubmed-article:19217150pubmed:day6lld:pubmed
pubmed-article:19217150pubmed:volume136lld:pubmed
pubmed-article:19217150pubmed:ownerNLMlld:pubmed
pubmed-article:19217150pubmed:authorsCompleteYlld:pubmed
pubmed-article:19217150pubmed:pagination839-51lld:pubmed
pubmed-article:19217150pubmed:dateRevised2009-11-19lld:pubmed
pubmed-article:19217150pubmed:meshHeadingpubmed-meshheading:19217150...lld:pubmed
pubmed-article:19217150pubmed:meshHeadingpubmed-meshheading:19217150...lld:pubmed
pubmed-article:19217150pubmed:meshHeadingpubmed-meshheading:19217150...lld:pubmed
pubmed-article:19217150pubmed:meshHeadingpubmed-meshheading:19217150...lld:pubmed
pubmed-article:19217150pubmed:meshHeadingpubmed-meshheading:19217150...lld:pubmed
pubmed-article:19217150pubmed:meshHeadingpubmed-meshheading:19217150...lld:pubmed
pubmed-article:19217150pubmed:meshHeadingpubmed-meshheading:19217150...lld:pubmed
pubmed-article:19217150pubmed:meshHeadingpubmed-meshheading:19217150...lld:pubmed
pubmed-article:19217150pubmed:meshHeadingpubmed-meshheading:19217150...lld:pubmed
pubmed-article:19217150pubmed:meshHeadingpubmed-meshheading:19217150...lld:pubmed
pubmed-article:19217150pubmed:meshHeadingpubmed-meshheading:19217150...lld:pubmed
pubmed-article:19217150pubmed:meshHeadingpubmed-meshheading:19217150...lld:pubmed
pubmed-article:19217150pubmed:meshHeadingpubmed-meshheading:19217150...lld:pubmed
pubmed-article:19217150pubmed:meshHeadingpubmed-meshheading:19217150...lld:pubmed
pubmed-article:19217150pubmed:year2009lld:pubmed
pubmed-article:19217150pubmed:articleTitleHeterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization.lld:pubmed
pubmed-article:19217150pubmed:affiliationVesalius Research Center, VIB-Vlaams Instituut voor Biotechnologie, Leuven, Belgium.lld:pubmed
pubmed-article:19217150pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19217150pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:112405entrezgene:pubmedpubmed-article:19217150lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:19217150lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19217150lld:pubmed