| pubmed-article:19204292 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19204292 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:19204292 | lifeskim:mentions | umls-concept:C0039198 | lld:lifeskim |
| pubmed-article:19204292 | lifeskim:mentions | umls-concept:C0021080 | lld:lifeskim |
| pubmed-article:19204292 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:19204292 | lifeskim:mentions | umls-concept:C0002520 | lld:lifeskim |
| pubmed-article:19204292 | lifeskim:mentions | umls-concept:C0021079 | lld:lifeskim |
| pubmed-article:19204292 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:19204292 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:19204292 | pubmed:dateCreated | 2009-3-4 | lld:pubmed |
| pubmed-article:19204292 | pubmed:abstractText | The T cell receptors from the regulatory IL-10-secreting T cell line induced by the random amino acid copolymers poly(F,Y,A,K,)n in SJL mice (H-2(s)) have been characterized, cloned, sequenced and expressed both in 293T cells and in 2 different TCR alpha(-)/beta(-) T cell hybridomas. The usage of TCR alpha and beta V regions in the cell line was oligoclonal. Four TCR alpha/beta pairs cloned from single cells of the T cell line were inserted into a retrovirus vector linked by an oligonucleotide encoding the 2A peptide that spontaneously cleaves in vivo. After cotransfection of this vector with a CD3 vector into the 293T cells, the TCR were surface expressed. Moreover, after transduction into the 2 T cell hybridomas, all 4 were functional as evidenced by their response to stimulation by poly(F,Y,A,K)n. All 4 pairs were Valpha3.2(3.5)/Vbeta14, a prominent clonotype found in the poly(F,Y,A,K)n-specific T cell line. These V regions are identical to those recently found in a regulatory T cell line that secretes both IL-4 and IL-10 induced in B10.PL mice with a different MHC hapotype (H-2(u)) by a small peptide obtained from an autoimmune TCR of that strain. These data lead to a hypothesis regarding the origin of the epigenetic modifications that lead to selective cytokine secretion in T cells. | lld:pubmed |
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| pubmed-article:19204292 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19204292 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19204292 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19204292 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19204292 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:19204292 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:19204292 | pubmed:author | pubmed-author:StromingerJac... | lld:pubmed |
| pubmed-article:19204292 | pubmed:author | pubmed-author:ZhangHongH | lld:pubmed |
| pubmed-article:19204292 | pubmed:author | pubmed-author:SternJoel N... | lld:pubmed |
| pubmed-article:19204292 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19204292 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:19204292 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:19204292 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19204292 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19204292 | pubmed:pagination | 3336-41 | lld:pubmed |
| pubmed-article:19204292 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:19204292 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19204292 | pubmed:articleTitle | T cell receptors in an IL-10-secreting amino acid copolymer-specific regulatory T cell line that mediates bystander immunosuppression. | lld:pubmed |
| pubmed-article:19204292 | pubmed:affiliation | Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. hzhang@mcb.harvard.edu | lld:pubmed |
| pubmed-article:19204292 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19204292 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19204292 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:16153 | entrezgene:pubmed | pubmed-article:19204292 | lld:entrezgene |
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