| pubmed-article:19204148 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19204148 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:19204148 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
| pubmed-article:19204148 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:19204148 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:19204148 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:19204148 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:19204148 | lifeskim:mentions | umls-concept:C0205144 | lld:lifeskim |
| pubmed-article:19204148 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:19204148 | pubmed:dateCreated | 2009-5-1 | lld:pubmed |
| pubmed-article:19204148 | pubmed:abstractText | Junctional adhesion molecule (JAM)-C is an Ig superfamily protein, which is involved in the regulation of various inflammatory and vascular events such as transendothelial leukocyte migration. JAM-C is expressed highly on the surface of endothelial cells and platelets, whereas expression in T lymphocytes is not well studied. To investigate the specific gene regulation of JAM-C in T lymphocytes, we determined JAM-C expression in quiescent and activated human T cells. Treatment with the polyclonal T cell activator PHA increased surface and total JAM-C expression in T cells time- and dose-dependently, as determined by flow cytometry and immunoblot analysis. In contrast, no up-regulation of JAM-A in activated T cells was detectable. The highest level of JAM-C up-regulation by PHA was observed in CD3(+)forkhead box P3(+) and CD4(+)CD25(high) T cells. Moreover, TCR activation with combined anti-CD3 and anti-CD28 stimulation induced JAM-C expression in T cells. JAM-C induction occurred at the mRNA level, suggesting a transcriptional regulatory mechanism of JAM-C expression. Accordingly, we studied the regulation of the human JAM-C gene promoter in transiently transfected T cells. Luciferase activity of a JAM-C promoter gene construct with three potential consensus sites for the transcription factor NFAT was induced markedly in activated T cells. Finally, pretreatment with two pharmacological inhibitors of calcineurin, cyclosporin A, and FK-506, but not with MAPK inhibitors, blocked JAM-C induction in activated T cells. In summary, JAM-C is up-regulated in activated human T lymphocytes via a transcriptional mechanism, suggesting a potential role of JAM-C in T cell functions. | lld:pubmed |
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| pubmed-article:19204148 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19204148 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19204148 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19204148 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19204148 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19204148 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19204148 | pubmed:month | May | lld:pubmed |
| pubmed-article:19204148 | pubmed:issn | 1938-3673 | lld:pubmed |
| pubmed-article:19204148 | pubmed:author | pubmed-author:ChavakisTrian... | lld:pubmed |
| pubmed-article:19204148 | pubmed:author | pubmed-author:SantosoSentot... | lld:pubmed |
| pubmed-article:19204148 | pubmed:author | pubmed-author:LudwigRalf... | lld:pubmed |
| pubmed-article:19204148 | pubmed:author | pubmed-author:ImmenschuhSte... | lld:pubmed |
| pubmed-article:19204148 | pubmed:author | pubmed-author:NaiduSrivatsa... | lld:pubmed |
| pubmed-article:19204148 | pubmed:author | pubmed-author:BeschmannHeik... | lld:pubmed |
| pubmed-article:19204148 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19204148 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:19204148 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19204148 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19204148 | pubmed:pagination | 796-803 | lld:pubmed |
| pubmed-article:19204148 | pubmed:dateRevised | 2010-9-22 | lld:pubmed |
| pubmed-article:19204148 | pubmed:meshHeading | pubmed-meshheading:19204148... | lld:pubmed |
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| pubmed-article:19204148 | pubmed:meshHeading | pubmed-meshheading:19204148... | lld:pubmed |
| pubmed-article:19204148 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19204148 | pubmed:articleTitle | Transcriptional induction of junctional adhesion molecule-C gene expression in activated T cells. | lld:pubmed |
| pubmed-article:19204148 | pubmed:affiliation | Institute for Transfusion Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. immenschuh.stephan@mh-hannover.de | lld:pubmed |
| pubmed-article:19204148 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19204148 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:83700 | entrezgene:pubmed | pubmed-article:19204148 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19204148 | lld:entrezgene |
