pubmed-article:19197851 | pubmed:abstractText | Lungs exposed to particulate debris may be damaged by proteolytic enzymes during phagocytosis. Damage is worse if patients are deficient in alpha1-antitrypsin (A1AT), which helps neutralise these enzymes. We investigated the possibility that A1AT deficiency contributes to aseptic loosening following total hip replacement (THR) when wear particles are phagocytosed. | lld:pubmed |