Linked Life Data

Plasma neutrophil elastase and elafin imbalance is associated with acute respiratory distress syndrome (ARDS) development.

Source:http://linkedlifedata.com/resource/pubmed/id/19197381

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Authors

Yu ZP, SU Kh, Christiani DC, Wang Z, Lin X, Zhai R, Thompson T, Zhang L

Affiliation

Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA. mikewang@hsph.harvard.edu

Abstract

We conducted an exploratory study of genome-wide gene expression in whole blood and found that the expression of neutrophil elastase inhibitor (PI3, elafin) was down-regulated during the early phase of ARDS. Further analyses of plasma PI3 levels revealed a rapid decrease during early ARDS development. PI3 and secretory leukocyte proteinase inhibitor (SLPI) are important low-molecular-weight proteinase inhibitors produced locally at neutrophil infiltration site in the lung. In this study, we tested the hypothesis that an imbalance between neutrophil elastase (HNE) and its inhibitors in blood is related to the development of ARDS.

PMID
19197381

Publication types

Research Support, N.I.H., Extramural