| pubmed-article:19197067 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19197067 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:19197067 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:19197067 | lifeskim:mentions | umls-concept:C0007708 | lld:lifeskim |
| pubmed-article:19197067 | lifeskim:mentions | umls-concept:C0242608 | lld:lifeskim |
| pubmed-article:19197067 | lifeskim:mentions | umls-concept:C1335083 | lld:lifeskim |
| pubmed-article:19197067 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:19197067 | lifeskim:mentions | umls-concept:C1707513 | lld:lifeskim |
| pubmed-article:19197067 | pubmed:issue | 5915 | lld:pubmed |
| pubmed-article:19197067 | pubmed:dateCreated | 2009-2-6 | lld:pubmed |
| pubmed-article:19197067 | pubmed:abstractText | Centrosomes, each containing a pair of centrioles, organize microtubules in animal cells, particularly during mitosis. DNA and centrosomes are normally duplicated once before cell division to maintain optimal genome integrity. We report a new role for the Orc1 protein, a subunit of the origin recognition complex (ORC) that is a key component of the DNA replication licensing machinery, in controlling centriole and centrosome copy number in human cells, independent of its role in DNA replication. Cyclin A promotes Orc1 localization to centrosomes where Orc1 prevents Cyclin E-dependent reduplication of both centrioles and centrosomes in a single cell division cycle. The data suggest that Orc1 is a regulator of centriole and centrosome reduplication as well as the initiation of DNA replication. | lld:pubmed |
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| pubmed-article:19197067 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19197067 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19197067 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19197067 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19197067 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19197067 | pubmed:issn | 1095-9203 | lld:pubmed |
| pubmed-article:19197067 | pubmed:author | pubmed-author:StillmanBruce... | lld:pubmed |
| pubmed-article:19197067 | pubmed:author | pubmed-author:PrasanthSupri... | lld:pubmed |
| pubmed-article:19197067 | pubmed:author | pubmed-author:HemerlyAdrian... | lld:pubmed |
| pubmed-article:19197067 | pubmed:author | pubmed-author:SiddiquiKhali... | lld:pubmed |
| pubmed-article:19197067 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19197067 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:19197067 | pubmed:volume | 323 | lld:pubmed |
| pubmed-article:19197067 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19197067 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19197067 | pubmed:pagination | 789-93 | lld:pubmed |
| pubmed-article:19197067 | pubmed:dateRevised | 2011-10-27 | lld:pubmed |
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| pubmed-article:19197067 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19197067 | pubmed:articleTitle | Orc1 controls centriole and centrosome copy number in human cells. | lld:pubmed |
| pubmed-article:19197067 | pubmed:affiliation | Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor 11724, NY, USA. | lld:pubmed |
| pubmed-article:19197067 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19197067 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19197067 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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