| pubmed-article:1918969 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1918969 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:1918969 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:1918969 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:1918969 | lifeskim:mentions | umls-concept:C1537647 | lld:lifeskim |
| pubmed-article:1918969 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:1918969 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:1918969 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:1918969 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:1918969 | pubmed:dateCreated | 1991-10-28 | lld:pubmed |
| pubmed-article:1918969 | pubmed:abstractText | The class II (Ia) MHC molecules are cell surface proteins that regulate the activation of T cells. B lymphocyte expression of class II molecules has been shown to be influenced by a number of external stimuli. It has been previously demonstrated that treatment of these cells with IL-4 leads to an increase in class II gene transcription at 18 h as well as to an increase in steady state class II mRNA. It has also been previously demonstrated that LPS treatment of splenic B cells from athymic mice results in a decrease in steady state mRNA encoding the A alpha class II protein. This decrease persists for at least 18 h. Nuclear run-on transcription assays now demonstrate that although steady state mRNA levels for A alpha are decreased by LPS treatment of athymic mouse lymphocytes, LPS does not decrease A alpha gene transcription, but rather modestly activates transcription of this class II gene. LPS and IL-4 have been demonstrated to be synergistic stimuli for a number of genes. Costimulation of splenic lymphocytes from athymic mice with IL-4 plus LPS leads to activation of transcription, but the increase in transcription is no more than that seen with IL-4 stimulation alone. However, in costimulated lymphocytes, steady state A alpha-encoding mRNA levels are intermediate between the increased levels seen with IL-4 stimulation and the decreased levels seen with LPS stimulation. Therefore, LPS and IL-4 act nonsynergistically in class II gene transcription and the effects of LPS in decreasing steady state mRNA are most likely posttranscriptional. An IL-4-inducible and an LPS-inducible DNA-binding protein have been previously identified in splenic lymphocytes from athymic mice. Both nuclear binding proteins form complexes with the same DNA fragments from a control region of the A alpha gene. These nucleoprotein complexes comigrate under nondenaturing conditions and display identical patterns of binding with a panel of oligonucleotide competitors. Oligonucleotides representing protein binding sites of the IL-4 and LPS-induced DNA-binding proteins cross-compete for protein binding. Therefore, the binding proteins induced by LPS and IL-4 are likely related, and may function at different efficiencies as activators of A alpha gene transcription. | lld:pubmed |
| pubmed-article:1918969 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1918969 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1918969 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1918969 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1918969 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1918969 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1918969 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1918969 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1918969 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:1918969 | pubmed:author | pubmed-author:GlimcherL HLH | lld:pubmed |
| pubmed-article:1918969 | pubmed:author | pubmed-author:GravalleseE... | lld:pubmed |
| pubmed-article:1918969 | pubmed:author | pubmed-author:BoothbyMM | lld:pubmed |
| pubmed-article:1918969 | pubmed:author | pubmed-author:DarlingJ MJM | lld:pubmed |
| pubmed-article:1918969 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1918969 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1918969 | pubmed:volume | 147 | lld:pubmed |
| pubmed-article:1918969 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1918969 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1918969 | pubmed:pagination | 2377-83 | lld:pubmed |
| pubmed-article:1918969 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1918969 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1918969 | pubmed:articleTitle | Role of lipopolysaccharide and IL-4 in control of transcription of the class II A alpha gene. | lld:pubmed |
| pubmed-article:1918969 | pubmed:affiliation | Department of Cancer Biology, Harvard School of Public Health, Boston, MA 02115. | lld:pubmed |
| pubmed-article:1918969 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1918969 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1918969 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1918969 | lld:pubmed |
