| pubmed-article:1918968 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1918968 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:1918968 | lifeskim:mentions | umls-concept:C1865782 | lld:lifeskim |
| pubmed-article:1918968 | lifeskim:mentions | umls-concept:C1524075 | lld:lifeskim |
| pubmed-article:1918968 | lifeskim:mentions | umls-concept:C0205296 | lld:lifeskim |
| pubmed-article:1918968 | lifeskim:mentions | umls-concept:C0337112 | lld:lifeskim |
| pubmed-article:1918968 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:1918968 | pubmed:dateCreated | 1991-10-28 | lld:pubmed |
| pubmed-article:1918968 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1918968 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1918968 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1918968 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1918968 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1918968 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1918968 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1918968 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1918968 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1918968 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1918968 | pubmed:abstractText | We describe three sets of natural (preimmune) polyreactive antibodies and Ag-induced antibodies that share the same VH-VL combinations. The amino acid homology in the VH and VL segments averaged 92%. These sets were found among 49 neonatal and adult natural mAb that were compared with 35 Ag-induced monoclonals produced during the memory response to phosphocholine (PC)-keyhole limpet hemocyanin. Both groups of monoclonals had been selected on the basis of a restricted fine specificity pattern, namely the ability to recognize PC-protein and p-nitrophenyl phosphocholine but not PC. All of the antibodies were tested for reactivity against a panel of 15 self and foreign Ag. Despite their common fine specificity as the basis for selection, 33/49 natural antibodies were poly/auto reactive whereas 0/35 Ag-induced antibodies had such poly/auto reactive properties. The natural antibodies were encoded by genes representing nine different VH families and several V kappa and V lambda families. There were a few replacement substitutions distinguishing the Ag-induced antibodies from the natural antibodies in each set; however, the most noteworthy difference was the extreme variability of CDR3 in the natural antibodies that differed in both length and amino acid sequence from each other and from Ag-induced antibodies. The results suggest that CDR3 of the H chain may play a critical role in distinguishing poly- from monospecific combining sites in natural and Ag-induced antibodies. | lld:pubmed |
| pubmed-article:1918968 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1918968 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1918968 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1918968 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1918968 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1918968 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1918968 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1918968 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1918968 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1918968 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1918968 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:1918968 | pubmed:author | pubmed-author:ChenCC | lld:pubmed |
| pubmed-article:1918968 | pubmed:author | pubmed-author:RittenbergM... | lld:pubmed |
| pubmed-article:1918968 | pubmed:author | pubmed-author:Stenzel-Poore... | lld:pubmed |
| pubmed-article:1918968 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1918968 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1918968 | pubmed:volume | 147 | lld:pubmed |
| pubmed-article:1918968 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1918968 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1918968 | pubmed:pagination | 2359-67 | lld:pubmed |
| pubmed-article:1918968 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1918968 | pubmed:meshHeading | pubmed-meshheading:1918968-... | lld:pubmed |
| pubmed-article:1918968 | pubmed:meshHeading | pubmed-meshheading:1918968-... | lld:pubmed |
| pubmed-article:1918968 | pubmed:meshHeading | pubmed-meshheading:1918968-... | lld:pubmed |
| pubmed-article:1918968 | pubmed:meshHeading | pubmed-meshheading:1918968-... | lld:pubmed |
| pubmed-article:1918968 | pubmed:meshHeading | pubmed-meshheading:1918968-... | lld:pubmed |
| pubmed-article:1918968 | pubmed:meshHeading | pubmed-meshheading:1918968-... | lld:pubmed |
| pubmed-article:1918968 | pubmed:meshHeading | pubmed-meshheading:1918968-... | lld:pubmed |
| pubmed-article:1918968 | pubmed:meshHeading | pubmed-meshheading:1918968-... | lld:pubmed |
| pubmed-article:1918968 | pubmed:meshHeading | pubmed-meshheading:1918968-... | lld:pubmed |
| pubmed-article:1918968 | pubmed:meshHeading | pubmed-meshheading:1918968-... | lld:pubmed |
| pubmed-article:1918968 | pubmed:meshHeading | pubmed-meshheading:1918968-... | lld:pubmed |
| pubmed-article:1918968 | pubmed:meshHeading | pubmed-meshheading:1918968-... | lld:pubmed |
| pubmed-article:1918968 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1918968 | pubmed:articleTitle | Natural auto- and polyreactive antibodies differing from antigen-induced antibodies in the H chain CDR3. | lld:pubmed |
| pubmed-article:1918968 | pubmed:affiliation | Department of Microbiology and Immunology, Oregon Health Sciences University, Portland 97201. | lld:pubmed |
| pubmed-article:1918968 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1918968 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1918968 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16142 | entrezgene:pubmed | pubmed-article:1918968 | lld:entrezgene |
| entrez-gene:110612 | entrezgene:pubmed | pubmed-article:1918968 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1918968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1918968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1918968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1918968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1918968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1918968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1918968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1918968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1918968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1918968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1918968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1918968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1918968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1918968 | lld:pubmed |
