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pubmed-article:19188178pubmed:abstractTextWe have shown previously that tumor infiltration by FOXP3+ regulatory T cells (Treg) is associated with increased relapse and shorter survival of patients with both in situ and invasive breast cancer. Because estrogen regulates Treg numbers in mice and promotes the proliferation of human Tregs, we hypothesized that blocking estrogen receptor-alpha signaling would abrogate Tregs and be associated with response to hormonal therapy and increased survival.lld:pubmed
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pubmed-article:19188178pubmed:articleTitleImmunomodulation of FOXP3+ regulatory T cells by the aromatase inhibitor letrozole in breast cancer patients.lld:pubmed
pubmed-article:19188178pubmed:affiliationMolecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.lld:pubmed
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