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pubmed-article:19180618pubmed:abstractTextAn adaptable approach: The first highly convergent stereoselective synthesis of feglymycin (see structure) and its enantiomer is based on the coupling of repeating peptide fragments. The use of weakly basic conditions throughout the synthesis suppressed the epimerization of sensitive aryl glycine units. Feglymycin has strong anti-HIV activity as well as potent (previously identified as weak) antibacterial activity against Staphylococcus aureus.lld:pubmed
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pubmed-article:19180618pubmed:year2009lld:pubmed
pubmed-article:19180618pubmed:articleTitleTotal synthesis of the antiviral peptide antibiotic feglymycin.lld:pubmed
pubmed-article:19180618pubmed:affiliationTechnische Universität Berlin, Fakultät II-Institut für Chemie, Strasse des 17. Juni 124, 10623 Berlin, Germany.lld:pubmed
pubmed-article:19180618pubmed:publicationTypeJournal Articlelld:pubmed
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