| pubmed-article:19179402 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19179402 | lifeskim:mentions | umls-concept:C0013216 | lld:lifeskim |
| pubmed-article:19179402 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:19179402 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:19179402 | lifeskim:mentions | umls-concept:C1568868 | lld:lifeskim |
| pubmed-article:19179402 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:19179402 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:19179402 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:19179402 | pubmed:dateCreated | 2009-2-19 | lld:pubmed |
| pubmed-article:19179402 | pubmed:abstractText | R-Spondin1 (RSpo1) is a novel secreted protein that augments canonical Wnt/beta-catenin signaling. We injected recombinant RSpo1 protein into transgenic Wnt reporter TOPGAL mice and have identified the oral mucosa as a target tissue for RSpo1. Administration of RSpo1 into normal mice triggered nuclear translocation of beta-catenin and resulted in increased basal layer cellularity, thickened mucosa, and elevated epithelial cell proliferation in tongue. We herein evaluated the therapeutic potential of RSpo1 in treating chemotherapy or radiotherapy-induced oral mucositis in several mouse models. Prophylactic treatment with RSpo1 dose-dependently overcame the reduction of basal layer epithelial cellularity, mucosal thickness, and epithelial cell proliferation in tongues of mice exposed to whole-body irradiation. RSpo1 administration also substantially alleviated tongue mucositis in the oral cavity of mice receiving concomitant 5-fluorouracil and x-ray radiation. Furthermore, RSpo1 significantly reduced the extent of tongue ulceration in mice receiving a single fraction, high dose head-only radiation in a dose-dependent manner. Moreover, combined therapy of RSpo1 and keratinocyte growth factor resulted in complete healing of tongue ulcers in mice subjected to snout-only irradiation. In conclusion, our results demonstrate RSpo1 to be a potent therapeutic agent for oral mucositis by enhancing basal layer epithelial regeneration and accelerating mucosal repair through up-regulation of Wnt/beta-catenin pathway. | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19179402 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19179402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179402 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19179402 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19179402 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:19179402 | pubmed:author | pubmed-author:ZhaoJingsongJ | lld:pubmed |
| pubmed-article:19179402 | pubmed:author | pubmed-author:KimKyung-AhKA | lld:pubmed |
| pubmed-article:19179402 | pubmed:author | pubmed-author:AboArieA | lld:pubmed |
| pubmed-article:19179402 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:19179402 | pubmed:author | pubmed-author:PalenciaServa... | lld:pubmed |
| pubmed-article:19179402 | pubmed:author | pubmed-author:WagleMarieM | lld:pubmed |
| pubmed-article:19179402 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19179402 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:19179402 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:19179402 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19179402 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19179402 | pubmed:pagination | 2331-6 | lld:pubmed |
| pubmed-article:19179402 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:19179402 | pubmed:meshHeading | pubmed-meshheading:19179402... | lld:pubmed |
| pubmed-article:19179402 | pubmed:meshHeading | pubmed-meshheading:19179402... | lld:pubmed |
| pubmed-article:19179402 | pubmed:meshHeading | pubmed-meshheading:19179402... | lld:pubmed |
| pubmed-article:19179402 | pubmed:meshHeading | pubmed-meshheading:19179402... | lld:pubmed |
| pubmed-article:19179402 | pubmed:meshHeading | pubmed-meshheading:19179402... | lld:pubmed |
| pubmed-article:19179402 | pubmed:meshHeading | pubmed-meshheading:19179402... | lld:pubmed |
| pubmed-article:19179402 | pubmed:meshHeading | pubmed-meshheading:19179402... | lld:pubmed |
| pubmed-article:19179402 | pubmed:meshHeading | pubmed-meshheading:19179402... | lld:pubmed |
| pubmed-article:19179402 | pubmed:meshHeading | pubmed-meshheading:19179402... | lld:pubmed |
| pubmed-article:19179402 | pubmed:meshHeading | pubmed-meshheading:19179402... | lld:pubmed |
| pubmed-article:19179402 | pubmed:meshHeading | pubmed-meshheading:19179402... | lld:pubmed |
| pubmed-article:19179402 | pubmed:meshHeading | pubmed-meshheading:19179402... | lld:pubmed |
| pubmed-article:19179402 | pubmed:meshHeading | pubmed-meshheading:19179402... | lld:pubmed |
| pubmed-article:19179402 | pubmed:meshHeading | pubmed-meshheading:19179402... | lld:pubmed |
| pubmed-article:19179402 | pubmed:meshHeading | pubmed-meshheading:19179402... | lld:pubmed |
| pubmed-article:19179402 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19179402 | pubmed:articleTitle | R-Spondin1 protects mice from chemotherapy or radiation-induced oral mucositis through the canonical Wnt/beta-catenin pathway. | lld:pubmed |
| pubmed-article:19179402 | pubmed:affiliation | Department of Research, Nuvelo, Inc., 201 Industrial Road, Suite 310, San Carlos, CA 94070, USA. jingsongzhao@yahoo.com | lld:pubmed |
| pubmed-article:19179402 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:12387 | entrezgene:pubmed | pubmed-article:19179402 | lld:entrezgene |
| entrez-gene:22408 | entrezgene:pubmed | pubmed-article:19179402 | lld:entrezgene |
| entrez-gene:192199 | entrezgene:pubmed | pubmed-article:19179402 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19179402 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19179402 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19179402 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19179402 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19179402 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19179402 | lld:pubmed |
