Linked Life Data

1917670

Source:http://linkedlifedata.com/resource/pubmed/id/1917670

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pubmed-article:1917670pubmed:abstractTextThe effects of excess iodine on the development of the thyroid gland of chick embryos was assessed following injections of potassium iodide prior to incubation. Iodide injection resulted in a significantly greater thyroid gland weight (goitre) on Day 18 of incubation and a delay in hatching. Histological studies of the thyroid gland on Day 12 of incubation revealed that iodide injection had inhibited thyroid follicle development. On Day 14, however, the thyroid glands of the iodide-treated embryos were indistinguishable from controls and on Day 18 the thyroid follicles of the iodide-injected embryos were clearly hypertrophied. In agreement with these light microscopical observations, electron microscopical examination showed conspicuous development of rough endoplasmic reticulum in the follicle cells of both iodide-treated 14 and 18 days old embryos and in those of the corresponding controls. Immunocytochemical studies of the pituitary of 18 days old embryos revealed a depletion of immunoreactive TSH suggesting that the iodide-induced hypertrophy of the thyroid was mediated by an activation of the thyrotropes. Iodide treatment was without effect on plasma levels of T3 and T4 for Day 18 embryos suggesting that the compensatory hypertrophy of the thyroid gland was sufficient to maintain circulating levels of thyroid hormones. The present results demonstrate that, in the embryonic chick thyroid, excess iodine produces effects which occur in two phases. The first phase consists of a transitory inhibition of the formation of follicles; it is followed by a second phase of compensatory hypertrophy resulting in goitre. The first phase probably results from a direct inhibitory effect of iodine on the developing thyroid whereas the second phase probably reflects a stimulation of the thyroid by TSH.lld:pubmed
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pubmed-article:1917670pubmed:authorpubmed-author:GuyPPlld:pubmed
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pubmed-article:1917670pubmed:pagination157-67lld:pubmed
pubmed-article:1917670pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:1917670pubmed:articleTitleEffects of excess iodine in chick embryo thyroid follicles: initial inhibition and subsequent hypertrophy.lld:pubmed
pubmed-article:1917670pubmed:affiliationDepartment of Anatomy, University of Ottawa, Faculty of Medicine, Ontario, Canada.lld:pubmed
pubmed-article:1917670pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1917670pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed