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pubmed-article:19169046pubmed:abstractTextStandard treatment for patients with advanced colorectal cancer (ACRC) includes fluoropyrimidines in combination with oxaliplatin or irinotecan. The addition of targeted agents such as bevacizumab and cetuximab to these chemotherapy backbones further improved outcome with survival rates. However, even after intensive treatment, most tumors will subsequently progress and some patients are offered experimental phase I therapies.lld:pubmed
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pubmed-article:19169046pubmed:copyrightInfoCopyright 2009 S. Karger AG, Basel.lld:pubmed
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pubmed-article:19169046pubmed:articleTitleClinical benefit of new targeted agents in phase I trials in patients with advanced colorectal cancer.lld:pubmed
pubmed-article:19169046pubmed:affiliationDrug Development Unit, Royal Marsden Hospital, London and Surrey, UK. hendrik-tobias.arkenau@icr.ac.uklld:pubmed
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