Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:1916651rdf:typepubmed:Citationlld:pubmed
pubmed-article:1916651lifeskim:mentionsumls-concept:C0008059lld:lifeskim
pubmed-article:1916651lifeskim:mentionsumls-concept:C0238598lld:lifeskim
pubmed-article:1916651lifeskim:mentionsumls-concept:C0013072lld:lifeskim
pubmed-article:1916651lifeskim:mentionsumls-concept:C0037313lld:lifeskim
pubmed-article:1916651lifeskim:mentionsumls-concept:C0078839lld:lifeskim
pubmed-article:1916651lifeskim:mentionsumls-concept:C1154417lld:lifeskim
pubmed-article:1916651lifeskim:mentionsumls-concept:C1979963lld:lifeskim
pubmed-article:1916651lifeskim:mentionsumls-concept:C0205263lld:lifeskim
pubmed-article:1916651lifeskim:mentionsumls-concept:C2003903lld:lifeskim
pubmed-article:1916651lifeskim:mentionsumls-concept:C0240526lld:lifeskim
pubmed-article:1916651pubmed:issue1lld:pubmed
pubmed-article:1916651pubmed:dateCreated1991-11-5lld:pubmed
pubmed-article:1916651pubmed:abstractTextOvernight blood sampling for repeated growth hormone (GH) assays, regarded as the most physiological assessment of GH status, may induce some disturbances in patients' sleep and then in the evaluation of GH secretion. We studied the influence of a hypnotic drug, zolpidem (10 mg), on nocturnal GH profiles (GH peak, time to first and maximum GH peak, area under the curve, mean integrated concentration) over two nights at a 7-day interval, in a double-blind cross-over design in a group of 12 young adult volunteers (27.9 +/- 4.3 years), and in a group of 12 children (10.8 +/- 2.3 years) with short stature, in a parallel double-blind study. Mean GH profiles showed no difference between zolpidem-treated subjects and placebo-treated controls, either in adults or in children. Although in these experimental conditions, sleep onset latency was significantly reduced with zolpidem in the adult volunteers, the mean time to first GH peak remained unchanged. Furthermore, GH profile did not relate with sleep duration, sleep onset latency or number of awakenings. A hypnotic drug, such as zolpidem, given at bedtime, is therefore devoided of effect on nocturnal GH profile and may be used in young children for overnight blood sampling when needed.lld:pubmed
pubmed-article:1916651pubmed:languageenglld:pubmed
pubmed-article:1916651pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1916651pubmed:citationSubsetIMlld:pubmed
pubmed-article:1916651pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1916651pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1916651pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1916651pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1916651pubmed:statusMEDLINElld:pubmed
pubmed-article:1916651pubmed:issn0301-0163lld:pubmed
pubmed-article:1916651pubmed:authorpubmed-author:MorselliP LPLlld:pubmed
pubmed-article:1916651pubmed:authorpubmed-author:ColleMMlld:pubmed
pubmed-article:1916651pubmed:authorpubmed-author:BianchettiGGlld:pubmed
pubmed-article:1916651pubmed:authorpubmed-author:RosenzweigPPlld:pubmed
pubmed-article:1916651pubmed:authorpubmed-author:RuedasEElld:pubmed
pubmed-article:1916651pubmed:authorpubmed-author:FuseauEElld:pubmed
pubmed-article:1916651pubmed:authorpubmed-author:RuffiéAAlld:pubmed
pubmed-article:1916651pubmed:issnTypePrintlld:pubmed
pubmed-article:1916651pubmed:volume35lld:pubmed
pubmed-article:1916651pubmed:ownerNLMlld:pubmed
pubmed-article:1916651pubmed:authorsCompleteYlld:pubmed
pubmed-article:1916651pubmed:pagination30-4lld:pubmed
pubmed-article:1916651pubmed:dateRevised2004-11-17lld:pubmed
pubmed-article:1916651pubmed:meshHeadingpubmed-meshheading:1916651-...lld:pubmed
pubmed-article:1916651pubmed:meshHeadingpubmed-meshheading:1916651-...lld:pubmed
pubmed-article:1916651pubmed:meshHeadingpubmed-meshheading:1916651-...lld:pubmed
pubmed-article:1916651pubmed:meshHeadingpubmed-meshheading:1916651-...lld:pubmed
pubmed-article:1916651pubmed:meshHeadingpubmed-meshheading:1916651-...lld:pubmed
pubmed-article:1916651pubmed:meshHeadingpubmed-meshheading:1916651-...lld:pubmed
pubmed-article:1916651pubmed:meshHeadingpubmed-meshheading:1916651-...lld:pubmed
pubmed-article:1916651pubmed:meshHeadingpubmed-meshheading:1916651-...lld:pubmed
pubmed-article:1916651pubmed:meshHeadingpubmed-meshheading:1916651-...lld:pubmed
pubmed-article:1916651pubmed:meshHeadingpubmed-meshheading:1916651-...lld:pubmed
pubmed-article:1916651pubmed:meshHeadingpubmed-meshheading:1916651-...lld:pubmed
pubmed-article:1916651pubmed:meshHeadingpubmed-meshheading:1916651-...lld:pubmed
pubmed-article:1916651pubmed:year1991lld:pubmed
pubmed-article:1916651pubmed:articleTitleNocturnal profile of growth hormone secretion during sleep induced by zolpidem: a double-blind study in young adults and children.lld:pubmed
pubmed-article:1916651pubmed:affiliationCentre Aquitain d'Explorations Endocriniennes Pédiatriques, Bordeaux, France.lld:pubmed
pubmed-article:1916651pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1916651pubmed:publicationTypeClinical Triallld:pubmed
pubmed-article:1916651pubmed:publicationTypeControlled Clinical Triallld:pubmed