| pubmed-article:19164539 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19164539 | lifeskim:mentions | umls-concept:C0021761 | lld:lifeskim |
| pubmed-article:19164539 | lifeskim:mentions | umls-concept:C0040113 | lld:lifeskim |
| pubmed-article:19164539 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:19164539 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:19164539 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:19164539 | pubmed:dateCreated | 2009-2-4 | lld:pubmed |
| pubmed-article:19164539 | pubmed:abstractText | The thymus represents the "cradle" for T cell development, with thymic stroma providing multiple soluble and membrane cues to developing thymocytes. Although IL-7 is recognized as an essential factor for thymopoiesis, the "environmental niche" of thymic IL-7 activity remains poorly characterized in vivo. Using bacterial artificial chromosome transgenic mice in which YFP is under control of IL-7 promoter, we identify a subset of thymic epithelial cells (TECs) that co-express YFP and high levels of Il7 transcripts (IL-7(hi) cells). IL-7(hi) TECs arise during early fetal development, persist throughout life, and co-express homeostatic chemokines (Ccl19, Ccl25, Cxcl12) and cytokines (Il15) that are critical for normal thymopoiesis. In the adult thymus, IL-7(hi) cells localize to the cortico-medullary junction and display traits of both cortical and medullary TECs. Interestingly, the frequency of IL-7(hi) cells decreases with age, suggesting a mechanism for the age-related thymic involution that is associated with declining IL-7 levels. Our temporal-spatial analysis of IL-7-producing cells in the thymus in vivo suggests that thymic IL-7 levels are dynamically regulated under distinct physiological conditions. This IL-7 reporter mouse provides a valuable tool to further dissect the mechanisms that govern thymic IL-7 expression in vivo. | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19164539 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19164539 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164539 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19164539 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19164539 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:19164539 | pubmed:author | pubmed-author:CumanoAnaA | lld:pubmed |
| pubmed-article:19164539 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:19164539 | pubmed:author | pubmed-author:BoydRichardR | lld:pubmed |
| pubmed-article:19164539 | pubmed:author | pubmed-author:AlvesNuno LNL | lld:pubmed |
| pubmed-article:19164539 | pubmed:author | pubmed-author:EberlGerardG | lld:pubmed |
| pubmed-article:19164539 | pubmed:author | pubmed-author:HuntingtonNic... | lld:pubmed |
| pubmed-article:19164539 | pubmed:author | pubmed-author:PedutoLucieL | lld:pubmed |
| pubmed-article:19164539 | pubmed:author | pubmed-author:Richard-Le... | lld:pubmed |
| pubmed-article:19164539 | pubmed:author | pubmed-author:ChidgeyAnnA | lld:pubmed |
| pubmed-article:19164539 | pubmed:author | pubmed-author:SousaAna... | lld:pubmed |
| pubmed-article:19164539 | pubmed:author | pubmed-author:RibeiroVera... | lld:pubmed |
| pubmed-article:19164539 | pubmed:author | pubmed-author:BordackAlliso... | lld:pubmed |
| pubmed-article:19164539 | pubmed:author | pubmed-author:VivesFrancina... | lld:pubmed |
| pubmed-article:19164539 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19164539 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:19164539 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:19164539 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19164539 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19164539 | pubmed:pagination | 1512-7 | lld:pubmed |
| pubmed-article:19164539 | pubmed:dateRevised | 2011-4-28 | lld:pubmed |
| pubmed-article:19164539 | pubmed:meshHeading | pubmed-meshheading:19164539... | lld:pubmed |
| pubmed-article:19164539 | pubmed:meshHeading | pubmed-meshheading:19164539... | lld:pubmed |
| pubmed-article:19164539 | pubmed:meshHeading | pubmed-meshheading:19164539... | lld:pubmed |
| pubmed-article:19164539 | pubmed:meshHeading | pubmed-meshheading:19164539... | lld:pubmed |
| pubmed-article:19164539 | pubmed:meshHeading | pubmed-meshheading:19164539... | lld:pubmed |
| pubmed-article:19164539 | pubmed:meshHeading | pubmed-meshheading:19164539... | lld:pubmed |
| pubmed-article:19164539 | pubmed:meshHeading | pubmed-meshheading:19164539... | lld:pubmed |
| pubmed-article:19164539 | pubmed:meshHeading | pubmed-meshheading:19164539... | lld:pubmed |
| pubmed-article:19164539 | pubmed:meshHeading | pubmed-meshheading:19164539... | lld:pubmed |
| pubmed-article:19164539 | pubmed:meshHeading | pubmed-meshheading:19164539... | lld:pubmed |
| pubmed-article:19164539 | pubmed:meshHeading | pubmed-meshheading:19164539... | lld:pubmed |
| pubmed-article:19164539 | pubmed:meshHeading | pubmed-meshheading:19164539... | lld:pubmed |
| pubmed-article:19164539 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19164539 | pubmed:articleTitle | Characterization of the thymic IL-7 niche in vivo. | lld:pubmed |
| pubmed-article:19164539 | pubmed:affiliation | Cytokines and Lymphoid Development Unit, Lymphocyte Development Unit, Plate-Forme Technologique Centre d'Ingénierie Génétique Murine, and Laboratory of Lymphoid Tissue Development, Institut Pasteur, Paris, France. | lld:pubmed |
| pubmed-article:19164539 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19164539 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16196 | entrezgene:pubmed | pubmed-article:19164539 | lld:entrezgene |
| entrez-gene:18613 | entrezgene:pubmed | pubmed-article:19164539 | lld:entrezgene |
| entrez-gene:19264 | entrezgene:pubmed | pubmed-article:19164539 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19164539 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19164539 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19164539 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19164539 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19164539 | lld:pubmed |
