| pubmed-article:19164144 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19164144 | lifeskim:mentions | umls-concept:C0314752 | lld:lifeskim |
| pubmed-article:19164144 | lifeskim:mentions | umls-concept:C0004610 | lld:lifeskim |
| pubmed-article:19164144 | lifeskim:mentions | umls-concept:C0282215 | lld:lifeskim |
| pubmed-article:19164144 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:19164144 | lifeskim:mentions | umls-concept:C0338237 | lld:lifeskim |
| pubmed-article:19164144 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:19164144 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19164144 | pubmed:dateCreated | 2009-3-20 | lld:pubmed |
| pubmed-article:19164144 | pubmed:abstractText | The role of combination antibiotic therapy with a beta-lactam and a fluoroquinolone for bacteremia caused by gram-negative bacilli, to our knowledge, has not been previously described. Much of the previous study of combination therapy has included beta-lactams and aminoglycosides. We conducted a large retrospective cohort study to evaluate 28-day all-cause mortality in patients with monomicrobial bacteremia due to aerobic gram-negative bacilli who received either a combination of beta-lactams and fluoroquinolones or beta-lactam monotherapy. We enrolled adult patients admitted to Mayo Clinic hospitals from 1 January 2001 to 31 October 2006 in the study. After stratification of patients by Pitt bacteremia scores, we used Cox regression models to estimate the hazard ratios (HR) for 28-day all-cause mortality after adjusting for the propensity to receive combination therapy. We identified 398 and 304 unique patients with bacteremia caused by gram-negative bacilli who received single and combination antibiotic therapy, respectively. In less severely ill patients with Pitt bacteremia scores of <4, combination therapy was associated with lower 28-day mortality than single therapy (4.2% [9 of 214] versus 8.8% [28 of 319]; adjusted HR, 0.44; 95% confidence interval [CI], 0.20 to 0.98; P = 0.044). In critically ill patients with Pitt bacteremia scores of >or=4, there was no difference in 28-day mortality between combination and single therapy (25.6% [23 of 90] versus 27.8% [22 of 79]; adjusted HR, 0.87; 95% CI, 0.47 to 1.62; P = 0.660). These findings were consistent for 14-day all-cause mortality. In this large cohort, we found for the first time that combination therapy with beta-lactams and fluoroquinolones was associated with a reduction in 28-day all-cause mortality among less severely ill patients with bacteremia caused by gram-negative bacilli. | lld:pubmed |
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| pubmed-article:19164144 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19164144 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19164144 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19164144 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19164144 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:19164144 | pubmed:issn | 1098-6596 | lld:pubmed |
| pubmed-article:19164144 | pubmed:author | pubmed-author:VetterEmily... | lld:pubmed |
| pubmed-article:19164144 | pubmed:author | pubmed-author:WilsonJohn... | lld:pubmed |
| pubmed-article:19164144 | pubmed:author | pubmed-author:BaddourLarry... | lld:pubmed |
| pubmed-article:19164144 | pubmed:author | pubmed-author:TleyjehImad... | lld:pubmed |
| pubmed-article:19164144 | pubmed:author | pubmed-author:Eckel-PassowJ... | lld:pubmed |
| pubmed-article:19164144 | pubmed:author | pubmed-author:LahrBrian DBD | lld:pubmed |
| pubmed-article:19164144 | pubmed:author | pubmed-author:ThomsenKristi... | lld:pubmed |
| pubmed-article:19164144 | pubmed:author | pubmed-author:Al-HasanMajdi... | lld:pubmed |
| pubmed-article:19164144 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19164144 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:19164144 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19164144 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19164144 | pubmed:pagination | 1386-94 | lld:pubmed |
| pubmed-article:19164144 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:19164144 | pubmed:meshHeading | pubmed-meshheading:19164144... | lld:pubmed |
| pubmed-article:19164144 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19164144 | pubmed:articleTitle | Beta-lactam and fluoroquinolone combination antibiotic therapy for bacteremia caused by gram-negative bacilli. | lld:pubmed |
| pubmed-article:19164144 | pubmed:affiliation | University of Kentucky Chandler Medical Center, Lexington, KY 40536, USA. majdi.alhasan@uky.edu | lld:pubmed |
| pubmed-article:19164144 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19164144 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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