| pubmed-article:19161245 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19161245 | lifeskim:mentions | umls-concept:C0442043 | lld:lifeskim |
| pubmed-article:19161245 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:19161245 | lifeskim:mentions | umls-concept:C0449258 | lld:lifeskim |
| pubmed-article:19161245 | lifeskim:mentions | umls-concept:C0029957 | lld:lifeskim |
| pubmed-article:19161245 | lifeskim:mentions | umls-concept:C1254042 | lld:lifeskim |
| pubmed-article:19161245 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:19161245 | lifeskim:mentions | umls-concept:C1707511 | lld:lifeskim |
| pubmed-article:19161245 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19161245 | pubmed:dateCreated | 2009-2-3 | lld:pubmed |
| pubmed-article:19161245 | pubmed:abstractText | Heterochronic genes function to ensure the timing of stage-specific developmental events in C. elegans. Mutations in these genes cause certain developmental programs to be executed in a precocious or retarded manner. Canonical precocious (loss-of-function) and retarded (gain-of-function) mutations in the lin-14 gene lead to elimination or reiteration of larval stage-specific cellular events. Here, we describe a hypomorphic, missense allele of lin-14, sa485. lin-14(sa485) hermaphrodites pass through normal larval stages, but exhibit asynchrony between vulval and gonadal maturation in the L4 larval stage. We show that a subtly precocious morphogenetic event in the vulva disrupts tissue synchrony and is followed by retarded vulval eversion. Additionally, uterine uv1 cell differentiation is retarded in lin-14(sa485) animals that exhibit delayed vulval eversion. Together, these experiments outline a function for LIN-14 in coordinating the temporal progression of development, which is separable from its role in regulating stage-specific events during C. elegans postembryonic development. | lld:pubmed |
| pubmed-article:19161245 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19161245 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19161245 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19161245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19161245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19161245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19161245 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19161245 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19161245 | pubmed:issn | 1058-8388 | lld:pubmed |
| pubmed-article:19161245 | pubmed:author | pubmed-author:Hanna-RoseWen... | lld:pubmed |
| pubmed-article:19161245 | pubmed:author | pubmed-author:ChamberlinHel... | lld:pubmed |
| pubmed-article:19161245 | pubmed:author | pubmed-author:JohnsonRyan... | lld:pubmed |
| pubmed-article:19161245 | pubmed:author | pubmed-author:LiuLeah YLY | lld:pubmed |
| pubmed-article:19161245 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19161245 | pubmed:volume | 238 | lld:pubmed |
| pubmed-article:19161245 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19161245 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19161245 | pubmed:pagination | 394-404 | lld:pubmed |
| pubmed-article:19161245 | pubmed:meshHeading | pubmed-meshheading:19161245... | lld:pubmed |
| pubmed-article:19161245 | pubmed:meshHeading | pubmed-meshheading:19161245... | lld:pubmed |
| pubmed-article:19161245 | pubmed:meshHeading | pubmed-meshheading:19161245... | lld:pubmed |
| pubmed-article:19161245 | pubmed:meshHeading | pubmed-meshheading:19161245... | lld:pubmed |
| pubmed-article:19161245 | pubmed:meshHeading | pubmed-meshheading:19161245... | lld:pubmed |
| pubmed-article:19161245 | pubmed:meshHeading | pubmed-meshheading:19161245... | lld:pubmed |
| pubmed-article:19161245 | pubmed:meshHeading | pubmed-meshheading:19161245... | lld:pubmed |
| pubmed-article:19161245 | pubmed:meshHeading | pubmed-meshheading:19161245... | lld:pubmed |
| pubmed-article:19161245 | pubmed:meshHeading | pubmed-meshheading:19161245... | lld:pubmed |
| pubmed-article:19161245 | pubmed:meshHeading | pubmed-meshheading:19161245... | lld:pubmed |
| pubmed-article:19161245 | pubmed:meshHeading | pubmed-meshheading:19161245... | lld:pubmed |
| pubmed-article:19161245 | pubmed:meshHeading | pubmed-meshheading:19161245... | lld:pubmed |
| pubmed-article:19161245 | pubmed:meshHeading | pubmed-meshheading:19161245... | lld:pubmed |
| pubmed-article:19161245 | pubmed:meshHeading | pubmed-meshheading:19161245... | lld:pubmed |
| pubmed-article:19161245 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19161245 | pubmed:articleTitle | The Caenorhabditis elegans heterochronic gene lin-14 coordinates temporal progression and maturation in the egg-laying system. | lld:pubmed |
| pubmed-article:19161245 | pubmed:affiliation | Department of Molecular Genetics, Ohio State University, Columbus, Ohio, USA. | lld:pubmed |
| pubmed-article:19161245 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19161245 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:19161245 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:181337 | entrezgene:pubmed | pubmed-article:19161245 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19161245 | lld:entrezgene |
