| pubmed-article:19159670 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19159670 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:19159670 | lifeskim:mentions | umls-concept:C0885003 | lld:lifeskim |
| pubmed-article:19159670 | lifeskim:mentions | umls-concept:C0017562 | lld:lifeskim |
| pubmed-article:19159670 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:19159670 | lifeskim:mentions | umls-concept:C2828366 | lld:lifeskim |
| pubmed-article:19159670 | lifeskim:mentions | umls-concept:C1705851 | lld:lifeskim |
| pubmed-article:19159670 | lifeskim:mentions | umls-concept:C1555707 | lld:lifeskim |
| pubmed-article:19159670 | lifeskim:mentions | umls-concept:C1515926 | lld:lifeskim |
| pubmed-article:19159670 | lifeskim:mentions | umls-concept:C0073590 | lld:lifeskim |
| pubmed-article:19159670 | lifeskim:mentions | umls-concept:C2752151 | lld:lifeskim |
| pubmed-article:19159670 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19159670 | pubmed:dateCreated | 2009-3-2 | lld:pubmed |
| pubmed-article:19159670 | pubmed:abstractText | Periodontitis is a chronic disease associated with inflammation of the tooth-supporting tissues. The inflammation is initiated by a group of gram-negative anaerobic bacteria. These express a number of irritating factors including a lipopolysaccharide (LPS), which plays a key role in periodontal disease development. Plant extracts with anti-inflammatory and anti-microbial properties have been shown to inhibit bacterial plaque formation and thus prevent chronic gingivitis. In this study we tested effects of Prunella vulgaris L. extract (PVE; 5, 10, 25microg/ml) and its component rosmarinic acid (RA; 1microg/ml) on LPS-induced oxidative damage and inflammation in human gingival fibroblasts. PVE and RA reduced reactive oxygen species (ROS) production, intracellular glutathione (GSH) depletion as well as lipid peroxidation in LPS-treated cells. Treatment with PVE and RA also inhibited LPS-induced up-regulation of interleukin 1beta (IL-1beta), interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and suppressed expression of inducible nitric oxide synthase (iNOS). The results indicate that PVE and RA are able to suppress LPS-induced biological changes in gingival fibroblasts. The effects of PVE and RA are presumably linked to their anti-inflammatory activities and thus use of PVE and RA may be relevant in modulating the inflammation process, including periodontal disease. | lld:pubmed |
| pubmed-article:19159670 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19159670 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19159670 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19159670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19159670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19159670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19159670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19159670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19159670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19159670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19159670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19159670 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19159670 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:19159670 | pubmed:issn | 0887-2333 | lld:pubmed |
| pubmed-article:19159670 | pubmed:author | pubmed-author:SimánekVV | lld:pubmed |
| pubmed-article:19159670 | pubmed:author | pubmed-author:SvobodováAA | lld:pubmed |
| pubmed-article:19159670 | pubmed:author | pubmed-author:UlrichováJJ | lld:pubmed |
| pubmed-article:19159670 | pubmed:author | pubmed-author:ZdarilováAA | lld:pubmed |
| pubmed-article:19159670 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19159670 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:19159670 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19159670 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19159670 | pubmed:pagination | 386-92 | lld:pubmed |
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| pubmed-article:19159670 | pubmed:meshHeading | pubmed-meshheading:19159670... | lld:pubmed |
| pubmed-article:19159670 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19159670 | pubmed:articleTitle | Prunella vulgaris extract and rosmarinic acid suppress lipopolysaccharide-induced alteration in human gingival fibroblasts. | lld:pubmed |
| pubmed-article:19159670 | pubmed:affiliation | Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Hnevotínská 3, Palacký University, 775 15 Olomouc, Czech Republic. | lld:pubmed |
| pubmed-article:19159670 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19159670 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19159670 | lld:pubmed |
