| pubmed-article:19159619 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19159619 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:19159619 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:19159619 | lifeskim:mentions | umls-concept:C0003209 | lld:lifeskim |
| pubmed-article:19159619 | lifeskim:mentions | umls-concept:C0206359 | lld:lifeskim |
| pubmed-article:19159619 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:19159619 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:19159619 | lifeskim:mentions | umls-concept:C0220807 | lld:lifeskim |
| pubmed-article:19159619 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:19159619 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:19159619 | lifeskim:mentions | umls-concept:C1515999 | lld:lifeskim |
| pubmed-article:19159619 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:19159619 | pubmed:dateCreated | 2009-3-24 | lld:pubmed |
| pubmed-article:19159619 | pubmed:abstractText | Many cancer chemopreventive agents have been associated with lower cancer risk by suppressing nuclear factor-kappaB (NF-kappaB) signaling pathways, which subsequently leads to attenuated pro-inflammatory mediators and activities. Of the natural compounds, the isothiocyanates (ITCs) found in cruciferous vegetables have received particular attention because of their potential anti-cancer effects. However, limited studies regarding the influence of ITCs structure on NF-kappaB transactivation and anti-inflammatory action are reported. In the present study, the anti-inflammatory potential of ten structurally divergent synthetic ITCs were evaluated in HT-29-N9 human colon cancer cells and RAW 264.7 murine macrophages. The effect of ITCs on the basal transcriptional activation of NF-kappaB and the inflammatory response to bacterial lipopolysaccharide (LPS) were assessed. The synthetic ITC analogs suppressed NF-kappaB-mediated pro-inflammatory gene transcription. Among the ITC analogs, tetrahydrofurfuryl isothiocyanate, methyl-3-isothiocyanatopropionate, 3-morpholinopropyl isothiocyanate and 3,4-methyelendioxybenzyl isothiocyanate showed stronger NF-kappaB inhibition as compared to the parent compound, phenylethyl isothiocyanate (PEITC). Molecular analysis revealed that several of the pro-inflammatory mediators and cytokines (iNOS, COX-2, IL-1beta, IL-6 and TNF-alpha) were reduced by ITCs, and correlated with the downregulation of NF-kappaB signaling pathways. Immunoblotting showed that ITCs suppressed LPS-induced phosphorylation and degradation of IkappaB alpha and decreased nuclear translocation of p65. In parallel, ITCs suppressed the phosphorylation of IkappaB kinase alpha/beta (IKKalpha/beta). Taken together, our findings provide the possibility that synthetic ITC analogs might have promising cancer chemopreventive potential, based on their stronger anti-NF-kappaB and anti-inflammatory activities, than the natural ITCs. | lld:pubmed |
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| pubmed-article:19159619 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19159619 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19159619 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19159619 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19159619 | pubmed:month | May | lld:pubmed |
| pubmed-article:19159619 | pubmed:issn | 1872-7786 | lld:pubmed |
| pubmed-article:19159619 | pubmed:author | pubmed-author:HuLongqinL | lld:pubmed |
| pubmed-article:19159619 | pubmed:author | pubmed-author:YuSiwangS | lld:pubmed |
| pubmed-article:19159619 | pubmed:author | pubmed-author:Tin OoKhorK | lld:pubmed |
| pubmed-article:19159619 | pubmed:author | pubmed-author:KeumYoung-Sam... | lld:pubmed |
| pubmed-article:19159619 | pubmed:author | pubmed-author:PrawanAuemdua... | lld:pubmed |
| pubmed-article:19159619 | pubmed:author | pubmed-author:SawConstance... | lld:pubmed |
| pubmed-article:19159619 | pubmed:author | pubmed-author:KongAh-NgAN | lld:pubmed |
| pubmed-article:19159619 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19159619 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:19159619 | pubmed:volume | 179 | lld:pubmed |
| pubmed-article:19159619 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19159619 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19159619 | pubmed:pagination | 202-11 | lld:pubmed |
| pubmed-article:19159619 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:19159619 | pubmed:meshHeading | pubmed-meshheading:19159619... | lld:pubmed |
