| pubmed-article:19158484 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19158484 | lifeskim:mentions | umls-concept:C0169665 | lld:lifeskim |
| pubmed-article:19158484 | lifeskim:mentions | umls-concept:C0026249 | lld:lifeskim |
| pubmed-article:19158484 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:19158484 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:19158484 | lifeskim:mentions | umls-concept:C1332737 | lld:lifeskim |
| pubmed-article:19158484 | lifeskim:mentions | umls-concept:C1705523 | lld:lifeskim |
| pubmed-article:19158484 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:19158484 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19158484 | pubmed:dateCreated | 2009-1-23 | lld:pubmed |
| pubmed-article:19158484 | pubmed:abstractText | How mitogens reduce the abundance of the cell cycle inhibitor p27(Kip1) is an important question, and regulation of p27(Kip1) translation and turnover has been described. Here we show that platelet-derived growth factor (PDGF) reduces the activity of the p27(Kip1) promoter and the abundance of the p27(Kip1) transcript in density-arrested mouse fibroblasts. Inhibition of p27(Kip1) gene expression by PDGF required protein synthesis and histone deacetylase activity but not Akt or ERK activity. PDGF increased the expression of c-Myc in the absence but not presence of a histone deacetylase inhibitor, and c-Myc inhibited p27(Kip1) promoter activity when ectopically expressed in fibroblasts. c-Myc targeted the same region of the p27(Kip1) promoter as did PDGF (deletion analysis) and interacted with this region in vivo (chromatin immunoprecipitation assay). Collectively, these findings suggest that c-Myc mediates the inhibitory effects of PDGF on the p27(Kip1) promoter. We also demonstrate reductions in p27(Kip1) mRNA abundance in primary splenocytes exposed to concanavalin A and in T cells exposed to interleukin-2 (IL-2). In contrast to PDGF in fibroblasts, IL-2 required Akt activity for maximal reductions in p27(Kip1) promoter activity and mRNA abundance in T cells. Thus, mitogens repress p27(Kip1) gene transcription in multiple systems and by multiple mechanisms. | lld:pubmed |
| pubmed-article:19158484 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19158484 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19158484 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19158484 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19158484 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19158484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19158484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19158484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19158484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19158484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19158484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19158484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19158484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19158484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19158484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19158484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19158484 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19158484 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19158484 | pubmed:issn | 1551-4005 | lld:pubmed |
| pubmed-article:19158484 | pubmed:author | pubmed-author:GoMMJr | lld:pubmed |
| pubmed-article:19158484 | pubmed:author | pubmed-author:CuiDongmingD | lld:pubmed |
| pubmed-article:19158484 | pubmed:author | pubmed-author:RoySangitaS | lld:pubmed |
| pubmed-article:19158484 | pubmed:author | pubmed-author:BaguiTapan... | lld:pubmed |
| pubmed-article:19158484 | pubmed:author | pubmed-author:MohapatraSubh... | lld:pubmed |
| pubmed-article:19158484 | pubmed:author | pubmed-author:PledgerW... | lld:pubmed |
| pubmed-article:19158484 | pubmed:author | pubmed-author:ShorAudrey... | lld:pubmed |
| pubmed-article:19158484 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19158484 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19158484 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:19158484 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19158484 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19158484 | pubmed:pagination | 115-24 | lld:pubmed |
| pubmed-article:19158484 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:19158484 | pubmed:meshHeading | pubmed-meshheading:19158484... | lld:pubmed |
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| pubmed-article:19158484 | pubmed:meshHeading | pubmed-meshheading:19158484... | lld:pubmed |
| pubmed-article:19158484 | pubmed:meshHeading | pubmed-meshheading:19158484... | lld:pubmed |
| pubmed-article:19158484 | pubmed:meshHeading | pubmed-meshheading:19158484... | lld:pubmed |
| pubmed-article:19158484 | pubmed:meshHeading | pubmed-meshheading:19158484... | lld:pubmed |
| pubmed-article:19158484 | pubmed:meshHeading | pubmed-meshheading:19158484... | lld:pubmed |
| pubmed-article:19158484 | pubmed:meshHeading | pubmed-meshheading:19158484... | lld:pubmed |
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| pubmed-article:19158484 | pubmed:meshHeading | pubmed-meshheading:19158484... | lld:pubmed |
| pubmed-article:19158484 | pubmed:meshHeading | pubmed-meshheading:19158484... | lld:pubmed |
| pubmed-article:19158484 | pubmed:meshHeading | pubmed-meshheading:19158484... | lld:pubmed |
| pubmed-article:19158484 | pubmed:meshHeading | pubmed-meshheading:19158484... | lld:pubmed |
| pubmed-article:19158484 | pubmed:meshHeading | pubmed-meshheading:19158484... | lld:pubmed |
| pubmed-article:19158484 | pubmed:meshHeading | pubmed-meshheading:19158484... | lld:pubmed |
| pubmed-article:19158484 | pubmed:meshHeading | pubmed-meshheading:19158484... | lld:pubmed |
| pubmed-article:19158484 | pubmed:meshHeading | pubmed-meshheading:19158484... | lld:pubmed |
| pubmed-article:19158484 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19158484 | pubmed:articleTitle | Inhibition of p27Kip1 gene transcription by mitogens. | lld:pubmed |
| pubmed-article:19158484 | pubmed:affiliation | Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA. | lld:pubmed |
| pubmed-article:19158484 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19158484 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19158484 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:12576 | entrezgene:pubmed | pubmed-article:19158484 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19158484 | lld:pubmed |
