Linked Life Data

19152396

Source:http://linkedlifedata.com/resource/pubmed/id/19152396

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:19152396rdf:typepubmed:Citationlld:pubmed
pubmed-article:19152396lifeskim:mentionsumls-concept:C0020094lld:lifeskim
pubmed-article:19152396lifeskim:mentionsumls-concept:C0237401lld:lifeskim
pubmed-article:19152396lifeskim:mentionsumls-concept:C0147139lld:lifeskim
pubmed-article:19152396lifeskim:mentionsumls-concept:C1335837lld:lifeskim
pubmed-article:19152396lifeskim:mentionsumls-concept:C1705603lld:lifeskim
pubmed-article:19152396lifeskim:mentionsumls-concept:C0076560lld:lifeskim
pubmed-article:19152396lifeskim:mentionsumls-concept:C0017337lld:lifeskim
pubmed-article:19152396lifeskim:mentionsumls-concept:C1336626lld:lifeskim
pubmed-article:19152396lifeskim:mentionsumls-concept:C0332281lld:lifeskim
pubmed-article:19152396lifeskim:mentionsumls-concept:C1527148lld:lifeskim
pubmed-article:19152396lifeskim:mentionsumls-concept:C1442734lld:lifeskim
pubmed-article:19152396lifeskim:mentionsumls-concept:C1882417lld:lifeskim
pubmed-article:19152396lifeskim:mentionsumls-concept:C0279477lld:lifeskim
pubmed-article:19152396lifeskim:mentionsumls-concept:C1704619lld:lifeskim
pubmed-article:19152396lifeskim:mentionsumls-concept:C1533179lld:lifeskim
pubmed-article:19152396lifeskim:mentionsumls-concept:C1880355lld:lifeskim
pubmed-article:19152396lifeskim:mentionsumls-concept:C0238815lld:lifeskim
pubmed-article:19152396pubmed:issue3lld:pubmed
pubmed-article:19152396pubmed:dateCreated2009-1-22lld:pubmed
pubmed-article:19152396pubmed:abstractTextThe development of HTLV-1 associated clinical manifestations, such as TSP/HAM and ATLL, occur in 2-4% of the infected population and it is still unclear why this infection remains asymptomatic in most infected carriers. Recently, it has been demonstrated that HTLV uses the Glucose transporter type 1 (GLUT1) to infect T-CD4(+) lymphocytes and that single nucleotide polymorphisms (SNP) in the GLUT1 gene are associated with diabetic nephropathy in patients with diabetes mellitus in different populations. These polymorphisms could contribute to a higher GLUT1 protein expression on cellular membrane, facilitating the entry of HTLV and its transmission cell by cell. This could result in a higher provirus load and consequently in the development of TSP/HAM. To evaluate the role of GLUT1 gene polymorphisms in the development of TSP/HAM in HTLV-1 infected individuals, the g.22999G > T, g.15339T > C and c.-2841A > T sites were analyzed by PCR/RFLP or sequencing in 244 infected individuals and 102 normal controls. The proviral load of the HTLV-1 infected patients was also analyzed using Real Time Quantitative PCR. Genotypic and allelic frequencies of the three sites did not differ significantly between controls and HTLV-1 infected individuals. There was no difference in genotypic and allelic distributions among patients as to the presence or absence of HTLV-1 associated clinic manifestations. As regards the quantification of the provirus load, we observed a significant reduction in the asymptomatic individuals compared with the oligosymptomatic and TSP/HAM individuals. These results suggest that g.22999G > T, g.15339T > C, and c.-2841A > T SNP do not contribute to HTLV-1 infection nor to the genetic susceptibility of TSP/HAM in Brazilian HTLV-1 infected individuals.lld:pubmed
pubmed-article:19152396pubmed:languageenglld:pubmed
pubmed-article:19152396pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19152396pubmed:citationSubsetIMlld:pubmed
pubmed-article:19152396pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19152396pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19152396pubmed:statusMEDLINElld:pubmed
pubmed-article:19152396pubmed:monthMarlld:pubmed
pubmed-article:19152396pubmed:issn1096-9071lld:pubmed
pubmed-article:19152396pubmed:authorpubmed-author:Galvão-Castro...lld:pubmed
pubmed-article:19152396pubmed:authorpubmed-author:TakayanaguiOs...lld:pubmed
pubmed-article:19152396pubmed:authorpubmed-author:CovasDimas...lld:pubmed
pubmed-article:19152396pubmed:authorpubmed-author:GadelhaSandra...lld:pubmed
pubmed-article:19152396pubmed:authorpubmed-author:CostaGiselle...lld:pubmed
pubmed-article:19152396pubmed:authorpubmed-author:AzevedoRochel...lld:pubmed
pubmed-article:19152396pubmed:authorpubmed-author:KashimaSimone...lld:pubmed
pubmed-article:19152396pubmed:authorpubmed-author:MuricyGabriel...lld:pubmed
pubmed-article:19152396pubmed:authorpubmed-author:OlavarriaVivi...lld:pubmed
pubmed-article:19152396pubmed:authorpubmed-author:AlcantaraLuiz...lld:pubmed
pubmed-article:19152396pubmed:copyrightInfoCopyright 2009 Wiley-Liss, Inc.lld:pubmed
pubmed-article:19152396pubmed:issnTypeElectroniclld:pubmed
pubmed-article:19152396pubmed:volume81lld:pubmed
pubmed-article:19152396pubmed:ownerNLMlld:pubmed
pubmed-article:19152396pubmed:authorsCompleteYlld:pubmed
pubmed-article:19152396pubmed:pagination552-7lld:pubmed
pubmed-article:19152396pubmed:meshHeadingpubmed-meshheading:19152396...lld:pubmed
pubmed-article:19152396pubmed:meshHeadingpubmed-meshheading:19152396...lld:pubmed
pubmed-article:19152396pubmed:meshHeadingpubmed-meshheading:19152396...lld:pubmed
pubmed-article:19152396pubmed:meshHeadingpubmed-meshheading:19152396...lld:pubmed
pubmed-article:19152396pubmed:meshHeadingpubmed-meshheading:19152396...lld:pubmed
pubmed-article:19152396pubmed:meshHeadingpubmed-meshheading:19152396...lld:pubmed
pubmed-article:19152396pubmed:meshHeadingpubmed-meshheading:19152396...lld:pubmed
pubmed-article:19152396pubmed:meshHeadingpubmed-meshheading:19152396...lld:pubmed
pubmed-article:19152396pubmed:meshHeadingpubmed-meshheading:19152396...lld:pubmed
pubmed-article:19152396pubmed:meshHeadingpubmed-meshheading:19152396...lld:pubmed
pubmed-article:19152396pubmed:meshHeadingpubmed-meshheading:19152396...lld:pubmed
pubmed-article:19152396pubmed:meshHeadingpubmed-meshheading:19152396...lld:pubmed
pubmed-article:19152396pubmed:year2009lld:pubmed
pubmed-article:19152396pubmed:articleTitlePolymorphisms at GLUT1 gene are not associated with the development of TSP/HAM in Brazilian HTLV-1 infected individuals and the discovery of a new polymorphism at GLUT1 gene.lld:pubmed
pubmed-article:19152396pubmed:affiliationLaboratório Avançado de Saúde Pública, Centro de Pesquisa Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil.lld:pubmed
pubmed-article:19152396pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19152396pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:6513entrezgene:pubmedpubmed-article:19152396lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:19152396lld:entrezgene