| pubmed-article:19144517 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19144517 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:19144517 | lifeskim:mentions | umls-concept:C1333336 | lld:lifeskim |
| pubmed-article:19144517 | lifeskim:mentions | umls-concept:C0062773 | lld:lifeskim |
| pubmed-article:19144517 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:19144517 | lifeskim:mentions | umls-concept:C0301039 | lld:lifeskim |
| pubmed-article:19144517 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19144517 | pubmed:dateCreated | 2009-2-16 | lld:pubmed |
| pubmed-article:19144517 | pubmed:abstractText | We identified a series of 4-hydroxyquinolines bearing a C1 to C15 alkyl chain at the C2 position and a carbethoxy/carboxy group at the C3 position of the quinoline nucleus (MC compounds), endowed with selective inhibitory activity against the p300/CBP HAT enzymes. Enzyme inhibition was investigated using in vitro HAT assays and by western blot analysis of cellular lysates to examine the acetylation levels of histone H3 and alpha-tubulin. When tested in U937 cells, some compounds displayed pro-apoptotic or cytodifferentiating properties. | lld:pubmed |
| pubmed-article:19144517 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19144517 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19144517 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19144517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19144517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19144517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19144517 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19144517 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19144517 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:19144517 | pubmed:author | pubmed-author:TiniMarcM | lld:pubmed |
| pubmed-article:19144517 | pubmed:author | pubmed-author:MaiAntonelloA | lld:pubmed |
| pubmed-article:19144517 | pubmed:author | pubmed-author:SbardellaGian... | lld:pubmed |
| pubmed-article:19144517 | pubmed:author | pubmed-author:CastellanoSab... | lld:pubmed |
| pubmed-article:19144517 | pubmed:author | pubmed-author:AltucciLuciaL | lld:pubmed |
| pubmed-article:19144517 | pubmed:author | pubmed-author:RotiliDanteD | lld:pubmed |
| pubmed-article:19144517 | pubmed:author | pubmed-author:NebbiosoAngel... | lld:pubmed |
| pubmed-article:19144517 | pubmed:author | pubmed-author:TarantinoDome... | lld:pubmed |
| pubmed-article:19144517 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19144517 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:19144517 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:19144517 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19144517 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19144517 | pubmed:pagination | 1132-5 | lld:pubmed |
| pubmed-article:19144517 | pubmed:meshHeading | pubmed-meshheading:19144517... | lld:pubmed |
| pubmed-article:19144517 | pubmed:meshHeading | pubmed-meshheading:19144517... | lld:pubmed |
| pubmed-article:19144517 | pubmed:meshHeading | pubmed-meshheading:19144517... | lld:pubmed |
| pubmed-article:19144517 | pubmed:meshHeading | pubmed-meshheading:19144517... | lld:pubmed |
| pubmed-article:19144517 | pubmed:meshHeading | pubmed-meshheading:19144517... | lld:pubmed |
| pubmed-article:19144517 | pubmed:meshHeading | pubmed-meshheading:19144517... | lld:pubmed |
| pubmed-article:19144517 | pubmed:meshHeading | pubmed-meshheading:19144517... | lld:pubmed |
| pubmed-article:19144517 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19144517 | pubmed:articleTitle | Identification of 4-hydroxyquinolines inhibitors of p300/CBP histone acetyltransferases. | lld:pubmed |
| pubmed-article:19144517 | pubmed:affiliation | Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, P.le A. Moro 5, 00185 Roma, Italy. antonello.mai@uniroma1.it | lld:pubmed |
| pubmed-article:19144517 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19144517 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:19144517 | lld:chembl |
