| pubmed-article:19144451 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19144451 | lifeskim:mentions | umls-concept:C0013227 | lld:lifeskim |
| pubmed-article:19144451 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:19144451 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:19144451 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:19144451 | lifeskim:mentions | umls-concept:C1333933 | lld:lifeskim |
| pubmed-article:19144451 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:19144451 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:19144451 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19144451 | pubmed:dateCreated | 2009-4-20 | lld:pubmed |
| pubmed-article:19144451 | pubmed:abstractText | We developed a structure-property-activity relationship (SPAR)-model for psychopharmacological drugs acting as non-competitive 5-HT(3A) receptor antagonists by using a decision-tree learner provided by the RapidMiner machine learning tool. A single molecular descriptor, namely the molecular dipole moment per molecular weight (mu/MW), predicts whether or not a substance non-competitively antagonizes 5-HT-induced Na(+) currents. A low mu/MW is compatible with drug-cumulation in apolar lipid rafts. This study confirms that size-intensive descriptors allow the development of compact SPAR models. | lld:pubmed |
| pubmed-article:19144451 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19144451 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19144451 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19144451 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19144451 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19144451 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19144451 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:19144451 | pubmed:issn | 1768-3254 | lld:pubmed |
| pubmed-article:19144451 | pubmed:author | pubmed-author:RupprechtRain... | lld:pubmed |
| pubmed-article:19144451 | pubmed:author | pubmed-author:WiltfangJensJ | lld:pubmed |
| pubmed-article:19144451 | pubmed:author | pubmed-author:BleichStefanS | lld:pubmed |
| pubmed-article:19144451 | pubmed:author | pubmed-author:KornhuberJoha... | lld:pubmed |
| pubmed-article:19144451 | pubmed:author | pubmed-author:TerflothLotha... | lld:pubmed |
| pubmed-article:19144451 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19144451 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:19144451 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19144451 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19144451 | pubmed:pagination | 2667-72 | lld:pubmed |
| pubmed-article:19144451 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:19144451 | pubmed:meshHeading | pubmed-meshheading:19144451... | lld:pubmed |
| pubmed-article:19144451 | pubmed:meshHeading | pubmed-meshheading:19144451... | lld:pubmed |
| pubmed-article:19144451 | pubmed:meshHeading | pubmed-meshheading:19144451... | lld:pubmed |
| pubmed-article:19144451 | pubmed:meshHeading | pubmed-meshheading:19144451... | lld:pubmed |
| pubmed-article:19144451 | pubmed:meshHeading | pubmed-meshheading:19144451... | lld:pubmed |
| pubmed-article:19144451 | pubmed:meshHeading | pubmed-meshheading:19144451... | lld:pubmed |
| pubmed-article:19144451 | pubmed:meshHeading | pubmed-meshheading:19144451... | lld:pubmed |
| pubmed-article:19144451 | pubmed:meshHeading | pubmed-meshheading:19144451... | lld:pubmed |
| pubmed-article:19144451 | pubmed:meshHeading | pubmed-meshheading:19144451... | lld:pubmed |
| pubmed-article:19144451 | pubmed:meshHeading | pubmed-meshheading:19144451... | lld:pubmed |
| pubmed-article:19144451 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19144451 | pubmed:articleTitle | Molecular properties of psychopharmacological drugs determining non-competitive inhibition of 5-HT3A receptors. | lld:pubmed |
| pubmed-article:19144451 | pubmed:affiliation | Department of Psychiatry and Psychotherapy, University of Erlangen, Schwabachanlage 6, D-91054 Erlangen, Germany. johannes.kornhuber@uk-erlangen.de | lld:pubmed |
| pubmed-article:19144451 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:19144451 | lld:chembl |
