| pubmed-article:19136940 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19136940 | lifeskim:mentions | umls-concept:C0072899 | lld:lifeskim |
| pubmed-article:19136940 | lifeskim:mentions | umls-concept:C0068563 | lld:lifeskim |
| pubmed-article:19136940 | lifeskim:mentions | umls-concept:C0107103 | lld:lifeskim |
| pubmed-article:19136940 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:19136940 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:19136940 | lifeskim:mentions | umls-concept:C1709060 | lld:lifeskim |
| pubmed-article:19136940 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:19136940 | lifeskim:mentions | umls-concept:C1505675 | lld:lifeskim |
| pubmed-article:19136940 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19136940 | pubmed:dateCreated | 2009-3-16 | lld:pubmed |
| pubmed-article:19136940 | pubmed:abstractText | Positive alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor modulators include benzamide compounds that allosterically modulate AMPA glutamate receptors. These small molecules that cross the blood-brain barrier have been shown to act as a neuroprotectant by increasing the levels of endogenous brain-derived neurotrophic factor (BDNF). Positive AMPA receptor modulators have also been shown to increase the levels of growth-associated protein-43 (GAP-43). GAP-43 plays a major role in many aspects of neuronal function in vertebrates. The goal of this study was to determine whether GAP-43 was important in mediating the actions of positive AMPA receptor modulator (S18986) and BDNF. Using cortical cultures from GAP-43 knockout and control mice, we show that (1) GAP-43 is upregulated in response to S18986 and BDNF in control cultures; (2) this upregulation of GAP-43 is essential for mediating the neuroprotective effects of S18986 and BDNF; (3) administration of S18986 and BDNF leads to an increase in the expression of the glutamate transporters GLT-1 and GLAST that are key to limiting excitotoxic cell death and this increase in GLT-1 and GLAST expression is completely blocked in the absence of GAP-43. Taken together this study concludes that GAP-43 is an important mediator of the neurotrophic effects of S18986 and BDNF on neuronal survival and plasticity, and is essential for the success of positive AMPA receptor modulator-BDNF-based neurotrophin therapy. | lld:pubmed |
| pubmed-article:19136940 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19136940 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136940 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19136940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136940 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19136940 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:19136940 | pubmed:issn | 1476-5403 | lld:pubmed |
| pubmed-article:19136940 | pubmed:author | pubmed-author:GuptaS KSK | lld:pubmed |
| pubmed-article:19136940 | pubmed:author | pubmed-author:SpeddingMM | lld:pubmed |
| pubmed-article:19136940 | pubmed:author | pubmed-author:MirtovA VAV | lld:pubmed |
| pubmed-article:19136940 | pubmed:author | pubmed-author:MannHH | lld:pubmed |
| pubmed-article:19136940 | pubmed:author | pubmed-author:MeiriK FKF | lld:pubmed |
| pubmed-article:19136940 | pubmed:author | pubmed-author:GressensPP | lld:pubmed |
| pubmed-article:19136940 | pubmed:author | pubmed-author:KusumSS | lld:pubmed |
| pubmed-article:19136940 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19136940 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:19136940 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19136940 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19136940 | pubmed:pagination | 624-37 | lld:pubmed |
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| pubmed-article:19136940 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19136940 | pubmed:articleTitle | GAP-43 is essential for the neurotrophic effects of BDNF and positive AMPA receptor modulator S18986. | lld:pubmed |
| pubmed-article:19136940 | pubmed:affiliation | National Brain Research Center, Manesar, Haryana, India. | lld:pubmed |
| pubmed-article:19136940 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19136940 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:19136940 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:14432 | entrezgene:pubmed | pubmed-article:19136940 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19136940 | lld:pubmed |
