| pubmed-article:19136665 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19136665 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:19136665 | lifeskim:mentions | umls-concept:C0206745 | lld:lifeskim |
| pubmed-article:19136665 | lifeskim:mentions | umls-concept:C0008350 | lld:lifeskim |
| pubmed-article:19136665 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:19136665 | lifeskim:mentions | umls-concept:C0163315 | lld:lifeskim |
| pubmed-article:19136665 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:19136665 | pubmed:dateCreated | 2009-4-8 | lld:pubmed |
| pubmed-article:19136665 | pubmed:abstractText | Quantitative trait mapping identified a locus colocalizing with L-Fabp, encoding liver fatty acid binding protein, as a positional candidate for murine gallstone susceptibility. When fed a lithogenic diet (LD) for 2 weeks, L-Fabp(-/-) mice became hypercholesterolemic with increased hepatic VLDL cholesterol secretion. Seventy-five percent of L-Fabp(-/-) mice developed solid gallstones compared with 6% of wild-type mice with an increased gallstone score (3.29 versus 0.62, respectively; P < 0.01). Hepatic free cholesterol content, biliary cholesterol secretion, and the cholesterol saturation index of hepatic bile were increased in LD-fed L-Fabp(-/-) mice. Chow-fed L-Fabp(-/-) mice demonstrated increased fecal bile acid (BA) excretion accompanied by decreased ileal Asbt expression. By contrast, there was an increased BA pool and decreased fecal BA excretion in LD-fed L-Fabp(-/-) mice, associated with increased proximal intestinal Asbt mRNA expression, suggesting that intestinal BA absorption was enhanced in LD-fed L-Fabp(-/-) mice. The increase in biliary BA secretion and enterohepatic pool size in LD-fed L-Fabp(-/-) mice was accompanied by downregulation of Cyp7a1 mRNA and increased intestinal mRNA abundance of Fgf-15, Fxr, and Fabp6. These findings suggest that changes in hepatic cholesterol metabolism and biliary lipid secretion as well as changes in enterohepatic BA metabolism increase gallstone susceptibility in LD fed L-Fabp(-/-) mice. | lld:pubmed |
| pubmed-article:19136665 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19136665 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19136665 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19136665 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19136665 | pubmed:month | May | lld:pubmed |
| pubmed-article:19136665 | pubmed:issn | 0022-2275 | lld:pubmed |
| pubmed-article:19136665 | pubmed:author | pubmed-author:YinZ RZR | lld:pubmed |
| pubmed-article:19136665 | pubmed:author | pubmed-author:DavidsonNicho... | lld:pubmed |
| pubmed-article:19136665 | pubmed:author | pubmed-author:KennedySusan... | lld:pubmed |
| pubmed-article:19136665 | pubmed:author | pubmed-author:NewberryEliza... | lld:pubmed |
| pubmed-article:19136665 | pubmed:author | pubmed-author:LuoJianyangJ | lld:pubmed |
| pubmed-article:19136665 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19136665 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:19136665 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19136665 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19136665 | pubmed:pagination | 977-87 | lld:pubmed |
| pubmed-article:19136665 | pubmed:dateRevised | 2010-9-23 | lld:pubmed |
| pubmed-article:19136665 | pubmed:meshHeading | pubmed-meshheading:19136665... | lld:pubmed |
| pubmed-article:19136665 | pubmed:meshHeading | pubmed-meshheading:19136665... | lld:pubmed |
| pubmed-article:19136665 | pubmed:meshHeading | pubmed-meshheading:19136665... | lld:pubmed |
| pubmed-article:19136665 | pubmed:meshHeading | pubmed-meshheading:19136665... | lld:pubmed |
| pubmed-article:19136665 | pubmed:meshHeading | pubmed-meshheading:19136665... | lld:pubmed |
| pubmed-article:19136665 | pubmed:meshHeading | pubmed-meshheading:19136665... | lld:pubmed |
| pubmed-article:19136665 | pubmed:meshHeading | pubmed-meshheading:19136665... | lld:pubmed |
| pubmed-article:19136665 | pubmed:meshHeading | pubmed-meshheading:19136665... | lld:pubmed |
| pubmed-article:19136665 | pubmed:meshHeading | pubmed-meshheading:19136665... | lld:pubmed |
| pubmed-article:19136665 | pubmed:meshHeading | pubmed-meshheading:19136665... | lld:pubmed |
| pubmed-article:19136665 | pubmed:meshHeading | pubmed-meshheading:19136665... | lld:pubmed |
| pubmed-article:19136665 | pubmed:meshHeading | pubmed-meshheading:19136665... | lld:pubmed |
| pubmed-article:19136665 | pubmed:meshHeading | pubmed-meshheading:19136665... | lld:pubmed |
| pubmed-article:19136665 | pubmed:meshHeading | pubmed-meshheading:19136665... | lld:pubmed |
| pubmed-article:19136665 | pubmed:meshHeading | pubmed-meshheading:19136665... | lld:pubmed |
| pubmed-article:19136665 | pubmed:meshHeading | pubmed-meshheading:19136665... | lld:pubmed |
| pubmed-article:19136665 | pubmed:meshHeading | pubmed-meshheading:19136665... | lld:pubmed |
| pubmed-article:19136665 | pubmed:meshHeading | pubmed-meshheading:19136665... | lld:pubmed |
| pubmed-article:19136665 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19136665 | pubmed:articleTitle | Increased susceptibility to diet-induced gallstones in liver fatty acid binding protein knockout mice. | lld:pubmed |
| pubmed-article:19136665 | pubmed:affiliation | Department of Medicine, Division of Gastroenterology, Washington University School of Medicine, St Louis, MO 63110, USA. | lld:pubmed |
| pubmed-article:19136665 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19136665 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19136665 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:14080 | entrezgene:pubmed | pubmed-article:19136665 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19136665 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19136665 | lld:pubmed |
