| pubmed-article:19128831 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19128831 | lifeskim:mentions | umls-concept:C0023487 | lld:lifeskim |
| pubmed-article:19128831 | lifeskim:mentions | umls-concept:C0230463 | lld:lifeskim |
| pubmed-article:19128831 | lifeskim:mentions | umls-concept:C1704257 | lld:lifeskim |
| pubmed-article:19128831 | lifeskim:mentions | umls-concept:C1704258 | lld:lifeskim |
| pubmed-article:19128831 | lifeskim:mentions | umls-concept:C1442161 | lld:lifeskim |
| pubmed-article:19128831 | lifeskim:mentions | umls-concept:C0449560 | lld:lifeskim |
| pubmed-article:19128831 | lifeskim:mentions | umls-concept:C1533148 | lld:lifeskim |
| pubmed-article:19128831 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:19128831 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:19128831 | pubmed:dateCreated | 2009-7-6 | lld:pubmed |
| pubmed-article:19128831 | pubmed:abstractText | Acute promyelocytic leukemia (APL) is characterized by the presence of a chromosomal rearrangement involving retinoic acid receptor alpha (RARalpha) gene generating the X-RARalpha fusion. We describe here a unique RARalpha gene rearrangement in a patient with M3r subtype of APL. Conventional cytogenetic analysis revealed Y-chromosome loss as the sole karyotypic anomaly. No X-RARalpha fusion was detected by fluorescence in situ hybridization (FISH) using PML/RARalpha dual-color dual-fusion translocation probe set, or RARalpha dual-color break apart rearrangement probe or reverse-transcription polymerase chain reaction (RT-PCR). However, FISH using RARalpha dual-color break apart rearrangement probe showed a deletion of the entire 3'-end of one allele of RARalpha gene. To our knowledge, this is the first documented APL with 3'RARalpha submicroscopic deletion which is not associated with X-RARalpha fusion. The molecular consequences of this anomaly remain to be elucidated. | lld:pubmed |
| pubmed-article:19128831 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19128831 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19128831 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19128831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19128831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19128831 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19128831 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:19128831 | pubmed:issn | 1873-5835 | lld:pubmed |
| pubmed-article:19128831 | pubmed:author | pubmed-author:ZhangJunJ | lld:pubmed |
| pubmed-article:19128831 | pubmed:author | pubmed-author:XueYongquanY | lld:pubmed |
| pubmed-article:19128831 | pubmed:author | pubmed-author:PanJinlanJ | lld:pubmed |
| pubmed-article:19128831 | pubmed:author | pubmed-author:WuYafangY | lld:pubmed |
| pubmed-article:19128831 | pubmed:author | pubmed-author:HanYongshengY | lld:pubmed |
| pubmed-article:19128831 | pubmed:author | pubmed-author:BaiShuxiaoS | lld:pubmed |
| pubmed-article:19128831 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19128831 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:19128831 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19128831 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19128831 | pubmed:pagination | 1433-5 | lld:pubmed |
| pubmed-article:19128831 | pubmed:meshHeading | pubmed-meshheading:19128831... | lld:pubmed |
| pubmed-article:19128831 | pubmed:meshHeading | pubmed-meshheading:19128831... | lld:pubmed |
| pubmed-article:19128831 | pubmed:meshHeading | pubmed-meshheading:19128831... | lld:pubmed |
| pubmed-article:19128831 | pubmed:meshHeading | pubmed-meshheading:19128831... | lld:pubmed |
| pubmed-article:19128831 | pubmed:meshHeading | pubmed-meshheading:19128831... | lld:pubmed |
| pubmed-article:19128831 | pubmed:meshHeading | pubmed-meshheading:19128831... | lld:pubmed |
| pubmed-article:19128831 | pubmed:meshHeading | pubmed-meshheading:19128831... | lld:pubmed |
| pubmed-article:19128831 | pubmed:meshHeading | pubmed-meshheading:19128831... | lld:pubmed |
| pubmed-article:19128831 | pubmed:meshHeading | pubmed-meshheading:19128831... | lld:pubmed |
| pubmed-article:19128831 | pubmed:meshHeading | pubmed-meshheading:19128831... | lld:pubmed |
| pubmed-article:19128831 | pubmed:meshHeading | pubmed-meshheading:19128831... | lld:pubmed |
| pubmed-article:19128831 | pubmed:meshHeading | pubmed-meshheading:19128831... | lld:pubmed |
| pubmed-article:19128831 | pubmed:meshHeading | pubmed-meshheading:19128831... | lld:pubmed |
| pubmed-article:19128831 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19128831 | pubmed:articleTitle | Y-chromosome loss as the sole karyotypic anomaly with 3'RARalpha submicroscopic deletion in a case of M3r subtype of acute promyelocytic leukemia. | lld:pubmed |
| pubmed-article:19128831 | pubmed:affiliation | The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, 188 Shizi Street, Suzhou, 215006, PR China. | lld:pubmed |
| pubmed-article:19128831 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19128831 | pubmed:publicationType | Case Reports | lld:pubmed |
| pubmed-article:19128831 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:5914 | entrezgene:pubmed | pubmed-article:19128831 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19128831 | lld:entrezgene |
