| pubmed-article:19125887 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19125887 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:19125887 | lifeskim:mentions | umls-concept:C0022702 | lld:lifeskim |
| pubmed-article:19125887 | lifeskim:mentions | umls-concept:C1323383 | lld:lifeskim |
| pubmed-article:19125887 | lifeskim:mentions | umls-concept:C1510827 | lld:lifeskim |
| pubmed-article:19125887 | lifeskim:mentions | umls-concept:C0037791 | lld:lifeskim |
| pubmed-article:19125887 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19125887 | pubmed:dateCreated | 2009-1-7 | lld:pubmed |
| pubmed-article:19125887 | pubmed:abstractText | The interaction between the T-cell receptor (TCR) and its peptide-major histocompatibility complex (pepMHC) ligand plays a critical role in determining the activity and specificity of the T cell. The binding properties associated with these interactions have now been studied in many systems, providing a framework for a mechanistic understanding of the initial events that govern T-cell function. There have been various other reviews that have described the structural and biochemical features of TCR : pepMHC interactions. Here we provide an overview of four areas that directly impact our understanding of T-cell function, as viewed from the perspective of the TCR : pepMHC interaction: (1) relationships between T-cell activity and TCR : pepMHC binding parameters, (2) TCR affinity, avidity and clustering, (3) influence of coreceptors on pepMHC binding by TCRs and T-cell activity, and (4) impact of TCR binding affinity on antigenic peptide specificity. | lld:pubmed |
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