| pubmed-article:19125156 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:19125156 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:19125156 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:19125156 | lifeskim:mentions | umls-concept:C1623047 | lld:lifeskim |
| pubmed-article:19125156 | lifeskim:mentions | umls-concept:C0332453 | lld:lifeskim |
| pubmed-article:19125156 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19125156 | pubmed:dateCreated | 2009-1-16 | lld:pubmed |
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| pubmed-article:19125156 | pubmed:abstractText | The pervasive influence of secreted Wnt signaling proteins in tissue homeostasis and tumorigenesis has galvanized efforts to identify small molecules that target Wnt-mediated cellular responses. By screening a diverse synthetic chemical library, we have discovered two new classes of small molecules that disrupt Wnt pathway responses; whereas one class inhibits the activity of Porcupine, a membrane-bound acyltransferase that is essential to the production of Wnt proteins, the other abrogates destruction of Axin proteins, which are suppressors of Wnt/beta-catenin pathway activity. With these small molecules, we establish a chemical genetic approach for studying Wnt pathway responses and stem cell function in adult tissue. We achieve transient, reversible suppression of Wnt/beta-catenin pathway response in vivo, and we establish a mechanism-based approach to target cancerous cell growth. The signal transduction mechanisms shown here to be chemically tractable additionally contribute to Wnt-independent signal transduction pathways and thus could be broadly exploited for chemical genetics and therapeutic goals. | lld:pubmed |
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| pubmed-article:19125156 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19125156 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19125156 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19125156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19125156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19125156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19125156 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19125156 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19125156 | pubmed:issn | 1552-4469 | lld:pubmed |
| pubmed-article:19125156 | pubmed:author | pubmed-author:NgoT STS | lld:pubmed |
| pubmed-article:19125156 | pubmed:author | pubmed-author:LuJianmingJ | lld:pubmed |
| pubmed-article:19125156 | pubmed:author | pubmed-author:TangWeiW | lld:pubmed |
| pubmed-article:19125156 | pubmed:author | pubmed-author:ChenBaozhiB | lld:pubmed |
| pubmed-article:19125156 | pubmed:author | pubmed-author:AmatrudaJames... | lld:pubmed |
| pubmed-article:19125156 | pubmed:author | pubmed-author:RothMichael... | lld:pubmed |
| pubmed-article:19125156 | pubmed:author | pubmed-author:LumLawrenceL | lld:pubmed |
| pubmed-article:19125156 | pubmed:author | pubmed-author:WilliamsNoell... | lld:pubmed |
| pubmed-article:19125156 | pubmed:author | pubmed-author:MaZhiqiangZ | lld:pubmed |
| pubmed-article:19125156 | pubmed:author | pubmed-author:HaoWayneW | lld:pubmed |
| pubmed-article:19125156 | pubmed:author | pubmed-author:WeiShuguangS | lld:pubmed |
| pubmed-article:19125156 | pubmed:author | pubmed-author:DodgeMichael... | lld:pubmed |
| pubmed-article:19125156 | pubmed:author | pubmed-author:FanChih-WeiCW | lld:pubmed |
| pubmed-article:19125156 | pubmed:author | pubmed-author:KilgoreJessic... | lld:pubmed |
| pubmed-article:19125156 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19125156 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:19125156 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19125156 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19125156 | pubmed:pagination | 100-7 | lld:pubmed |
| pubmed-article:19125156 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:19125156 | pubmed:meshHeading | pubmed-meshheading:19125156... | lld:pubmed |
| pubmed-article:19125156 | pubmed:meshHeading | pubmed-meshheading:19125156... | lld:pubmed |
| pubmed-article:19125156 | pubmed:meshHeading | pubmed-meshheading:19125156... | lld:pubmed |
| pubmed-article:19125156 | pubmed:meshHeading | pubmed-meshheading:19125156... | lld:pubmed |
| pubmed-article:19125156 | pubmed:meshHeading | pubmed-meshheading:19125156... | lld:pubmed |
| pubmed-article:19125156 | pubmed:meshHeading | pubmed-meshheading:19125156... | lld:pubmed |
| pubmed-article:19125156 | pubmed:meshHeading | pubmed-meshheading:19125156... | lld:pubmed |
| pubmed-article:19125156 | pubmed:meshHeading | pubmed-meshheading:19125156... | lld:pubmed |
| pubmed-article:19125156 | pubmed:meshHeading | pubmed-meshheading:19125156... | lld:pubmed |
| pubmed-article:19125156 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19125156 | pubmed:articleTitle | Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. | lld:pubmed |
| pubmed-article:19125156 | pubmed:affiliation | Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA. | lld:pubmed |
| pubmed-article:19125156 | pubmed:publicationType | Journal Article | lld:pubmed |
