| pubmed-article:19124244 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19124244 | lifeskim:mentions | umls-concept:C1095827 | lld:lifeskim |
| pubmed-article:19124244 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:19124244 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19124244 | pubmed:dateCreated | 2009-1-27 | lld:pubmed |
| pubmed-article:19124244 | pubmed:abstractText | Phytochemical investigation from the stem bark of Butea monosperma, led to the isolation and identification of three new compounds named buteaspermin A (1), buteaspermin B (2) and buteaspermanol (3), along with 19 known compounds. The structure of compounds 1-22 were established on the basis of their spectroscopic data. The isolated compounds 2-17 were evaluated using neonatal (1-3 day old) rat calvaria derived primary osteoblast cultures. Five of these compounds 7, 10-13 showed promising osteogenic activity, attributed to increased osteoblast proliferation, differentiation and mineralization as evidenced by marked increase in expression of alkaline phosphatase, an early phase differentiation marker, and alizarin Red S staining of osteoblasts cultured for 48 h and von Kossa silver staining of nodules formed 15 days after culture with these compounds. Quantification of mineralization by optical density measurement of Alizarin Red S extracted from stained osteoblasts cultured for 7 days in presence of these compounds showed significant (P<0.05, vs corresponding vehicle control group) increase in mineralization. On the basis of biological results, structure-activity relationships are discussed. | lld:pubmed |
| pubmed-article:19124244 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19124244 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19124244 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19124244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19124244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19124244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19124244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19124244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19124244 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19124244 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19124244 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:19124244 | pubmed:author | pubmed-author:SahaiMahendra... | lld:pubmed |
| pubmed-article:19124244 | pubmed:author | pubmed-author:SinghMan... | lld:pubmed |
| pubmed-article:19124244 | pubmed:author | pubmed-author:MauryaRakeshR | lld:pubmed |
| pubmed-article:19124244 | pubmed:author | pubmed-author:SinghGeetuG | lld:pubmed |
| pubmed-article:19124244 | pubmed:author | pubmed-author:YadavDinesh... | lld:pubmed |
| pubmed-article:19124244 | pubmed:author | pubmed-author:Narayana... | lld:pubmed |
| pubmed-article:19124244 | pubmed:author | pubmed-author:BhargavanBiju... | lld:pubmed |
| pubmed-article:19124244 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19124244 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19124244 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:19124244 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19124244 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19124244 | pubmed:pagination | 610-3 | lld:pubmed |
| pubmed-article:19124244 | pubmed:meshHeading | pubmed-meshheading:19124244... | lld:pubmed |
| pubmed-article:19124244 | pubmed:meshHeading | pubmed-meshheading:19124244... | lld:pubmed |
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| pubmed-article:19124244 | pubmed:meshHeading | pubmed-meshheading:19124244... | lld:pubmed |
| pubmed-article:19124244 | pubmed:meshHeading | pubmed-meshheading:19124244... | lld:pubmed |
| pubmed-article:19124244 | pubmed:meshHeading | pubmed-meshheading:19124244... | lld:pubmed |
| pubmed-article:19124244 | pubmed:meshHeading | pubmed-meshheading:19124244... | lld:pubmed |
| pubmed-article:19124244 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19124244 | pubmed:articleTitle | Osteogenic activity of constituents from Butea monosperma. | lld:pubmed |
| pubmed-article:19124244 | pubmed:affiliation | Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar MAnzil Palace, M. G. Marg, Lucknow 226 001, Uttar Pradesh, India. mauryarakesh@rediffmail.com | lld:pubmed |
| pubmed-article:19124244 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19124244 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:19124244 | lld:chembl |
