| pubmed-article:19119867 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19119867 | lifeskim:mentions | umls-concept:C0003374 | lld:lifeskim |
| pubmed-article:19119867 | lifeskim:mentions | umls-concept:C0008269 | lld:lifeskim |
| pubmed-article:19119867 | lifeskim:mentions | umls-concept:C0035973 | lld:lifeskim |
| pubmed-article:19119867 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:19119867 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:19119867 | lifeskim:mentions | umls-concept:C1704241 | lld:lifeskim |
| pubmed-article:19119867 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:19119867 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:19119867 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:19119867 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19119867 | pubmed:dateCreated | 2009-1-29 | lld:pubmed |
| pubmed-article:19119867 | pubmed:abstractText | The new Ru(II) chloroquine complexes [Ru(eta(6)-arene)(CQ)Cl2] (CQ = chloroquine; arene = p-cymene 1, benzene 2), [Ru(eta(6)-p-cymene)(CQ)(H2O)2][BF4]2 (3), [Ru(eta(6)-p-cymene)(CQ)(en)][PF6]2 (en = ethylenediamine) (4), and [Ru(eta(6)-p-cymene)(eta(6)-CQDP)][BF4]2 (5, CQDP = chloroquine diphosphate) have been synthesized and characterized by use of a combination of NMR and FTIR spectroscopy with DFT calculations. Each complex is formed as a single coordination isomer: In 1-4, chloroquine binds to ruthenium in the eta(1)-N mode through the quinoline nitrogen atom, whereas in 5 an unprecedented eta(6) bonding through the carbocyclic ring is observed. 1, 2, 3, and 5 are active against CQ-resistant (Dd2, K1, and W2) and CQ-sensitive (FcB1, PFB, F32, and 3D7) malaria parasites (Plasmodium falciparum); importantly, the potency of these complexes against resistant parasites is consistently higher than that of the standard drug chloroquine diphosphate. 1 and 5 also inhibit the growth of colon cancer cells, independently of the p53 status and of liposarcoma tumor cell lines with the latter showing increased sensitivity, especially to 1 (IC50 8 microM); this is significant because this type of tumor does not respond to currently employed chemotherapies. | lld:pubmed |
| pubmed-article:19119867 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19119867 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19119867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19119867 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19119867 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19119867 | pubmed:issn | 1520-510X | lld:pubmed |
| pubmed-article:19119867 | pubmed:author | pubmed-author:SchwartzGary... | lld:pubmed |
| pubmed-article:19119867 | pubmed:author | pubmed-author:MartínezAlber... | lld:pubmed |
| pubmed-article:19119867 | pubmed:author | pubmed-author:AmbrosiniGraz... | lld:pubmed |
| pubmed-article:19119867 | pubmed:author | pubmed-author:SuárezLiliana... | lld:pubmed |
| pubmed-article:19119867 | pubmed:author | pubmed-author:Sánchez-Delga... | lld:pubmed |
| pubmed-article:19119867 | pubmed:author | pubmed-author:Deregnaucourt... | lld:pubmed |
| pubmed-article:19119867 | pubmed:author | pubmed-author:SchrévelJosep... | lld:pubmed |
| pubmed-article:19119867 | pubmed:author | pubmed-author:SinouVéroniqu... | lld:pubmed |
| pubmed-article:19119867 | pubmed:author | pubmed-author:JarzeckiAndrz... | lld:pubmed |
| pubmed-article:19119867 | pubmed:author | pubmed-author:MusiElgildaE | lld:pubmed |
| pubmed-article:19119867 | pubmed:author | pubmed-author:RajapakseChan... | lld:pubmed |
| pubmed-article:19119867 | pubmed:author | pubmed-author:NaoulouBeckyB | lld:pubmed |
| pubmed-article:19119867 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19119867 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:19119867 | pubmed:volume | 48 | lld:pubmed |
| pubmed-article:19119867 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19119867 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19119867 | pubmed:pagination | 1122-31 | lld:pubmed |
| pubmed-article:19119867 | pubmed:dateRevised | 2011-6-2 | lld:pubmed |
| pubmed-article:19119867 | pubmed:meshHeading | pubmed-meshheading:19119867... | lld:pubmed |
| pubmed-article:19119867 | pubmed:meshHeading | pubmed-meshheading:19119867... | lld:pubmed |
| pubmed-article:19119867 | pubmed:meshHeading | pubmed-meshheading:19119867... | lld:pubmed |
| pubmed-article:19119867 | pubmed:meshHeading | pubmed-meshheading:19119867... | lld:pubmed |
| pubmed-article:19119867 | pubmed:meshHeading | pubmed-meshheading:19119867... | lld:pubmed |
| pubmed-article:19119867 | pubmed:meshHeading | pubmed-meshheading:19119867... | lld:pubmed |
| pubmed-article:19119867 | pubmed:meshHeading | pubmed-meshheading:19119867... | lld:pubmed |
| pubmed-article:19119867 | pubmed:meshHeading | pubmed-meshheading:19119867... | lld:pubmed |
| pubmed-article:19119867 | pubmed:meshHeading | pubmed-meshheading:19119867... | lld:pubmed |
| pubmed-article:19119867 | pubmed:meshHeading | pubmed-meshheading:19119867... | lld:pubmed |
| pubmed-article:19119867 | pubmed:meshHeading | pubmed-meshheading:19119867... | lld:pubmed |
| pubmed-article:19119867 | pubmed:meshHeading | pubmed-meshheading:19119867... | lld:pubmed |
| pubmed-article:19119867 | pubmed:meshHeading | pubmed-meshheading:19119867... | lld:pubmed |
| pubmed-article:19119867 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19119867 | pubmed:articleTitle | Synthesis, characterization, and in vitro antimalarial and antitumor activity of new ruthenium(II) complexes of chloroquine. | lld:pubmed |
| pubmed-article:19119867 | pubmed:affiliation | Chemistry Department, Brooklyn College and The Graduate Center, The City University of New York, Brooklyn, New York 11210, USA. | lld:pubmed |
| pubmed-article:19119867 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19119867 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19119867 | lld:pubmed |
