| pubmed-article:19114304 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19114304 | lifeskim:mentions | umls-concept:C1512474 | lld:lifeskim |
| pubmed-article:19114304 | lifeskim:mentions | umls-concept:C0268563 | lld:lifeskim |
| pubmed-article:19114304 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:19114304 | lifeskim:mentions | umls-concept:C1328819 | lld:lifeskim |
| pubmed-article:19114304 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:19114304 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:19114304 | lifeskim:mentions | umls-concept:C1611588 | lld:lifeskim |
| pubmed-article:19114304 | lifeskim:mentions | umls-concept:C0053139 | lld:lifeskim |
| pubmed-article:19114304 | lifeskim:mentions | umls-concept:C1831850 | lld:lifeskim |
| pubmed-article:19114304 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19114304 | pubmed:dateCreated | 2009-1-27 | lld:pubmed |
| pubmed-article:19114304 | pubmed:abstractText | Analogues of the clinical compound MGCD0103 (A) were designed and synthesized. These compounds inhibit recombinant human HDAC1 with IC(50) values in the sub-micromolar range. In human cancer cells growing in culture these compounds induce hyperacetylation of histones, cause expression of the tumor suppressor protein p21(WAF1/CIP1), and inhibit cellular proliferation. Lead molecule of the series, compound 25 is metabolically stable, possesses favorable pharmacokinetic characteristics and is orally active in vivo in different mouse tumor xenograft models. | lld:pubmed |
| pubmed-article:19114304 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19114304 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19114304 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19114304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19114304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19114304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19114304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19114304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19114304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19114304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19114304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19114304 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19114304 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19114304 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:19114304 | pubmed:author | pubmed-author:MurakamiKojiK | lld:pubmed |
| pubmed-article:19114304 | pubmed:author | pubmed-author:WangJamesJ | lld:pubmed |
| pubmed-article:19114304 | pubmed:author | pubmed-author:LiuJianhongJ | lld:pubmed |
| pubmed-article:19114304 | pubmed:author | pubmed-author:DelormeDaniel... | lld:pubmed |
| pubmed-article:19114304 | pubmed:author | pubmed-author:BestermanJeff... | lld:pubmed |
| pubmed-article:19114304 | pubmed:author | pubmed-author:VaisburgArkad... | lld:pubmed |
| pubmed-article:19114304 | pubmed:author | pubmed-author:MoradeiOscarO | lld:pubmed |
| pubmed-article:19114304 | pubmed:author | pubmed-author:LeitSilvanaS | lld:pubmed |
| pubmed-article:19114304 | pubmed:author | pubmed-author:FournelMariel... | lld:pubmed |
| pubmed-article:19114304 | pubmed:author | pubmed-author:Trachy-Bourge... | lld:pubmed |
| pubmed-article:19114304 | pubmed:author | pubmed-author:LiZuomeiZ | lld:pubmed |
| pubmed-article:19114304 | pubmed:author | pubmed-author:KalitaAnnA | lld:pubmed |
| pubmed-article:19114304 | pubmed:author | pubmed-author:PaquinIsabell... | lld:pubmed |
| pubmed-article:19114304 | pubmed:author | pubmed-author:ZhouNancyN | lld:pubmed |
| pubmed-article:19114304 | pubmed:author | pubmed-author:FréchetteSylv... | lld:pubmed |
| pubmed-article:19114304 | pubmed:author | pubmed-author:RaeppelStépha... | lld:pubmed |
| pubmed-article:19114304 | pubmed:author | pubmed-author:GaudetteFrédé... | lld:pubmed |
| pubmed-article:19114304 | pubmed:author | pubmed-author:LuAihuaA | lld:pubmed |
| pubmed-article:19114304 | pubmed:author | pubmed-author:RahilJubrailJ | lld:pubmed |
| pubmed-article:19114304 | pubmed:author | pubmed-author:YanPu... | lld:pubmed |
| pubmed-article:19114304 | pubmed:author | pubmed-author:LaroucheGuill... | lld:pubmed |
| pubmed-article:19114304 | pubmed:author | pubmed-author:IsakovicLjubo... | lld:pubmed |
| pubmed-article:19114304 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19114304 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19114304 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:19114304 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19114304 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19114304 | pubmed:pagination | 644-9 | lld:pubmed |
| pubmed-article:19114304 | pubmed:meshHeading | pubmed-meshheading:19114304... | lld:pubmed |
| pubmed-article:19114304 | pubmed:meshHeading | pubmed-meshheading:19114304... | lld:pubmed |
| pubmed-article:19114304 | pubmed:meshHeading | pubmed-meshheading:19114304... | lld:pubmed |
| pubmed-article:19114304 | pubmed:meshHeading | pubmed-meshheading:19114304... | lld:pubmed |
| pubmed-article:19114304 | pubmed:meshHeading | pubmed-meshheading:19114304... | lld:pubmed |
| pubmed-article:19114304 | pubmed:meshHeading | pubmed-meshheading:19114304... | lld:pubmed |
| pubmed-article:19114304 | pubmed:meshHeading | pubmed-meshheading:19114304... | lld:pubmed |
| pubmed-article:19114304 | pubmed:meshHeading | pubmed-meshheading:19114304... | lld:pubmed |
| pubmed-article:19114304 | pubmed:meshHeading | pubmed-meshheading:19114304... | lld:pubmed |
| pubmed-article:19114304 | pubmed:meshHeading | pubmed-meshheading:19114304... | lld:pubmed |
| pubmed-article:19114304 | pubmed:meshHeading | pubmed-meshheading:19114304... | lld:pubmed |
| pubmed-article:19114304 | pubmed:meshHeading | pubmed-meshheading:19114304... | lld:pubmed |
| pubmed-article:19114304 | pubmed:meshHeading | pubmed-meshheading:19114304... | lld:pubmed |
| pubmed-article:19114304 | pubmed:meshHeading | pubmed-meshheading:19114304... | lld:pubmed |
| pubmed-article:19114304 | pubmed:meshHeading | pubmed-meshheading:19114304... | lld:pubmed |
| pubmed-article:19114304 | pubmed:meshHeading | pubmed-meshheading:19114304... | lld:pubmed |
| pubmed-article:19114304 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19114304 | pubmed:articleTitle | SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103). | lld:pubmed |
| pubmed-article:19114304 | pubmed:affiliation | MethylGene Inc., Department of Medicinal Chemistry, 7220 Frederick-Banting, Montréal, Que., Canada H4S 2A1. raeppels@methylgene.com | lld:pubmed |
| pubmed-article:19114304 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:19114304 | lld:chembl |
