| pubmed-article:19109199 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19109199 | lifeskim:mentions | umls-concept:C0002390 | lld:lifeskim |
| pubmed-article:19109199 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:19109199 | lifeskim:mentions | umls-concept:C0034069 | lld:lifeskim |
| pubmed-article:19109199 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:19109199 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:19109199 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19109199 | pubmed:dateCreated | 2008-12-25 | lld:pubmed |
| pubmed-article:19109199 | pubmed:abstractText | Hypersensitivity pneumonitis is an environmental lung disease characterized by a diffuse mononuclear cell infiltrate in the lung that can progress to pulmonary fibrosis with chronic exposure to an inhaled Ag. Using a well-established murine model of hypersensitivity pneumonitis, we repeatedly exposed C57BL/6 mice to Saccharopolyspora rectivirgula to investigate whether T cells are required for lung fibrosis. In the absence of alphabeta T cells, TCRbeta(-/-) mice exposed to S. rectivirgula for 4 wk had markedly decreased mononuclear infiltrates and collagen deposition in the lung compared with wild-type C57BL/6 mice. In contrast to CD8(+) T cells, adoptive transfer of CD4(+) T cells reconstituted the S. rectivirgula-induced inflammatory and fibrotic response, suggesting that the CD4(+) T cell represents the critical alphabeta T cell subset. Cytokine analysis of lung homogenates at various time points after S. rectivirgula exposure failed to identify a predominant Th1 or Th2 phenotype. Conversely, IL-17 was found in the lung at increasing concentrations with continued exposure to S. rectivirgula. Intracellular cytokine staining revealed that 14% of CD4(+) T cells from the lung of mice treated with S. rectivirgula expressed IL-17A. In the absence of IL-17 receptor signaling, Il17ra(-/-) mice had significantly decreased lung inflammation and fibrosis compared with wild-type C57BL/6 mice. These data are the first to demonstrate an important role for Th17-polarized CD4(+) T lymphocytes in the immune response directed against S. rectivirgula in this murine model of hypersensitivity pneumonitis and pulmonary fibrosis. | lld:pubmed |
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| pubmed-article:19109199 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19109199 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19109199 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:19109199 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19109199 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19109199 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:19109199 | pubmed:author | pubmed-author:WilmoreDD | lld:pubmed |
| pubmed-article:19109199 | pubmed:author | pubmed-author:FontenotAndre... | lld:pubmed |
| pubmed-article:19109199 | pubmed:author | pubmed-author:O'BrienRebecc... | lld:pubmed |
| pubmed-article:19109199 | pubmed:author | pubmed-author:RoarkChristin... | lld:pubmed |
| pubmed-article:19109199 | pubmed:author | pubmed-author:Diaz del... | lld:pubmed |
| pubmed-article:19109199 | pubmed:author | pubmed-author:SimonianPhili... | lld:pubmed |
| pubmed-article:19109199 | pubmed:author | pubmed-author:LanhamAllison... | lld:pubmed |
| pubmed-article:19109199 | pubmed:author | pubmed-author:WehrmannFabia... | lld:pubmed |
| pubmed-article:19109199 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19109199 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19109199 | pubmed:volume | 182 | lld:pubmed |
| pubmed-article:19109199 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19109199 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19109199 | pubmed:pagination | 657-65 | lld:pubmed |
| pubmed-article:19109199 | pubmed:dateRevised | 2011-5-6 | lld:pubmed |
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