| pubmed-article:19100287 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19100287 | lifeskim:mentions | umls-concept:C0032343 | lld:lifeskim |
| pubmed-article:19100287 | lifeskim:mentions | umls-concept:C0814002 | lld:lifeskim |
| pubmed-article:19100287 | lifeskim:mentions | umls-concept:C0679466 | lld:lifeskim |
| pubmed-article:19100287 | lifeskim:mentions | umls-concept:C0037643 | lld:lifeskim |
| pubmed-article:19100287 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:19100287 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:19100287 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19100287 | pubmed:dateCreated | 2009-1-26 | lld:pubmed |
| pubmed-article:19100287 | pubmed:abstractText | To date, treatment of organophosphate (OP) poisoning shows several shortcomings, and OP-victims might suffer from lasting cognitive deficits and sleep-wake disturbances. In the present study, long-term effects of soman poisoning on learning ability, memory and neurogenesis were investigated in rats, treated with the anticholinergic atropine and the oxime HI-6 for reactivation of soman-inhibited acetylcholinesterase. We also investigated whether sub-chronic treatment with the reported neurogenesis enhancer olanzapine would stimulate neurogenesis and possibly normalize the anticipated long-term deleterious effects of soman intoxication. Animals were treated with HI-6 (125 mg/kg i.p.), followed after 30 min by soman (200 microg/kg s.c.) and atropine sulphate (16 mg/kg i.m.) 1 min thereafter. Soman poisoning led to an elevation of extracellular acetylcholine levels to 1500% over baseline values as assessed by striatal microdialysis. Brain acetylcholinesterase was inhibited over 95%. This was accompanied by short recurrent seizures lasting for 40 min. Osmotic minipumps releasing olanzapine (7.5 mg/kg/day) or vehicle were subcutaneously implanted 24 h post-intoxication. After drug delivery for 4 weeks, newborn cells were BrdU labeled. Learning and memory performance were assessed 8 weeks after soman poisoning, followed by analysis of surviving newborn cells (BrdU) and neurogenesis (doublecortin, DCX). Eight weeks after soman-intoxication a significantly impaired learning ability was found that was paralleled by significantly lower numbers of DCX-positive cells but no changes in the number of BrdU-labeled cells. Apparently, the present Olanzapine regime was ineffective. We conclude that soman poisoning has long lasting effects on learning ability, a finding that was accompanied by impaired neurogenesis. Although we confirm a correlation between impaired neurogenesis and cognitive deficits, establishing the true causal relationship between these processes in OP exposed animals awaits future research. | lld:pubmed |
| pubmed-article:19100287 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19100287 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19100287 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19100287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19100287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19100287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19100287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19100287 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19100287 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19100287 | pubmed:issn | 0161-813X | lld:pubmed |
| pubmed-article:19100287 | pubmed:author | pubmed-author:SmitAugust... | lld:pubmed |
| pubmed-article:19100287 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:19100287 | pubmed:author | pubmed-author:JoosenMarloes... | lld:pubmed |
| pubmed-article:19100287 | pubmed:author | pubmed-author:LucassenPaul... | lld:pubmed |
| pubmed-article:19100287 | pubmed:author | pubmed-author:KuijpersWille... | lld:pubmed |
| pubmed-article:19100287 | pubmed:author | pubmed-author:JousmaEdwinE | lld:pubmed |
| pubmed-article:19100287 | pubmed:author | pubmed-author:van den... | lld:pubmed |
| pubmed-article:19100287 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19100287 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:19100287 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19100287 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19100287 | pubmed:pagination | 72-80 | lld:pubmed |
| pubmed-article:19100287 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:19100287 | pubmed:meshHeading | pubmed-meshheading:19100287... | lld:pubmed |
| pubmed-article:19100287 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19100287 | pubmed:articleTitle | Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoning. | lld:pubmed |
| pubmed-article:19100287 | pubmed:affiliation | TNO Defence, Security and Safety, BU Biological and Chemical Protection, Rijswijk, The Netherlands. marloes.joosen@tno.nl | lld:pubmed |
| pubmed-article:19100287 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19100287 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19100287 | lld:pubmed |
