| pubmed-article:1909341 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1909341 | lifeskim:mentions | umls-concept:C0302908 | lld:lifeskim |
| pubmed-article:1909341 | lifeskim:mentions | umls-concept:C0085237 | lld:lifeskim |
| pubmed-article:1909341 | lifeskim:mentions | umls-concept:C0680730 | lld:lifeskim |
| pubmed-article:1909341 | lifeskim:mentions | umls-concept:C1148554 | lld:lifeskim |
| pubmed-article:1909341 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1909341 | pubmed:dateCreated | 1991-10-4 | lld:pubmed |
| pubmed-article:1909341 | pubmed:abstractText | A sensitive high-performance liquid chromatographic assay was developed for the determination of tocainide enantiomers in plasma. Following extraction of tocainide from plasma, the enantiomers were derivatized with S-(+)-1-(1-naphthyl)ethylisocyanate. The resulting diastereomers were separated and quantified using normal-phase chromatography with fluorescence detection set at 220/345 nm (excitation/emission). The peaks, resolved with a resolution factor greater than 1.5, were free from interference. Linearity was established over the concentration range 0.25-10.0 mg/l for each enantiomer in plasma (r2 greater than 0.998). The inter-assay variability was less than 10% at all concentrations examined. The method can be used to determine the pharmacokinetics of tocainide enantiomers in man. | lld:pubmed |
| pubmed-article:1909341 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1909341 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1909341 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1909341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1909341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1909341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1909341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1909341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1909341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1909341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1909341 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1909341 | pubmed:month | May | lld:pubmed |
| pubmed-article:1909341 | pubmed:issn | 0021-9673 | lld:pubmed |
| pubmed-article:1909341 | pubmed:author | pubmed-author:FreitagDD | lld:pubmed |
| pubmed-article:1909341 | pubmed:author | pubmed-author:CarrR ARA | lld:pubmed |
| pubmed-article:1909341 | pubmed:author | pubmed-author:FosterR TRT | lld:pubmed |
| pubmed-article:1909341 | pubmed:author | pubmed-author:PasuttoF MFM | lld:pubmed |
| pubmed-article:1909341 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1909341 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:1909341 | pubmed:volume | 566 | lld:pubmed |
| pubmed-article:1909341 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1909341 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1909341 | pubmed:pagination | 155-62 | lld:pubmed |
| pubmed-article:1909341 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:1909341 | pubmed:meshHeading | pubmed-meshheading:1909341-... | lld:pubmed |
| pubmed-article:1909341 | pubmed:meshHeading | pubmed-meshheading:1909341-... | lld:pubmed |
| pubmed-article:1909341 | pubmed:meshHeading | pubmed-meshheading:1909341-... | lld:pubmed |
| pubmed-article:1909341 | pubmed:meshHeading | pubmed-meshheading:1909341-... | lld:pubmed |
| pubmed-article:1909341 | pubmed:meshHeading | pubmed-meshheading:1909341-... | lld:pubmed |
| pubmed-article:1909341 | pubmed:meshHeading | pubmed-meshheading:1909341-... | lld:pubmed |
| pubmed-article:1909341 | pubmed:meshHeading | pubmed-meshheading:1909341-... | lld:pubmed |
| pubmed-article:1909341 | pubmed:meshHeading | pubmed-meshheading:1909341-... | lld:pubmed |
| pubmed-article:1909341 | pubmed:meshHeading | pubmed-meshheading:1909341-... | lld:pubmed |
| pubmed-article:1909341 | pubmed:meshHeading | pubmed-meshheading:1909341-... | lld:pubmed |
| pubmed-article:1909341 | pubmed:meshHeading | pubmed-meshheading:1909341-... | lld:pubmed |
| pubmed-article:1909341 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1909341 | pubmed:articleTitle | Stereospecific high-performance liquid chromatographic determination of tocainide. | lld:pubmed |
| pubmed-article:1909341 | pubmed:affiliation | Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada. | lld:pubmed |
| pubmed-article:1909341 | pubmed:publicationType | Journal Article | lld:pubmed |
