| pubmed-article:1907849 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1907849 | lifeskim:mentions | umls-concept:C0023418 | lld:lifeskim |
| pubmed-article:1907849 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:1907849 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:1907849 | lifeskim:mentions | umls-concept:C1623430 | lld:lifeskim |
| pubmed-article:1907849 | lifeskim:mentions | umls-concept:C1706384 | lld:lifeskim |
| pubmed-article:1907849 | lifeskim:mentions | umls-concept:C1512310 | lld:lifeskim |
| pubmed-article:1907849 | lifeskim:mentions | umls-concept:C0010711 | lld:lifeskim |
| pubmed-article:1907849 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:1907849 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1907849 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:1907849 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:1907849 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:1907849 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:1907849 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:1907849 | pubmed:issue | 32 | lld:pubmed |
| pubmed-article:1907849 | pubmed:dateCreated | 1991-9-13 | lld:pubmed |
| pubmed-article:1907849 | pubmed:abstractText | 1-beta-D-Arabinofuranosylcytosine (ara-C) is an effective chemotherapeutic agent that incorporates into DNA and results in DNA fragmentation. Recent work has demonstrated that ara-C transiently induces expression of the c-jun immediate early response gene. The present studies in HL-60 myeloid leukemia cells extend these findings by demonstrating that the increase in c-jun mRNA levels at 6 h of ara-C treatment is regulated by a transcriptional mechanism. In contrast, the subsequent down-regulation of c-jun expression is controlled by a posttranscriptional decrease in the stability of the c-jun transcripts. Previous work in phorbol ester treated cells has indicated that c-jun expression is regulated by the activation of protein kinase C. The present results demonstrate that protein kinase C activity is increased in ara-C-treated cells. This increase was maximal at 60 min and remained detectable through 6 h of ara-C exposure. Moreover, the induction of c-jun transcripts by ara-C was inhibited by the isoquinolinesulfonamide derivative H7, but not by HA1004, suggesting that this effect is mediated by protein kinase C. Ara-C-induced c-jun expression was also inhibited by staurosporine, another inhibitor of protein kinase C. Taken together, these results indicate that the cellular response to ara-C includes the activation of protein kinase C and that ara-C potentially induces c-jun transcription by a protein kinase C dependent signaling mechanism. | lld:pubmed |
| pubmed-article:1907849 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1907849 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1907849 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1907849 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1907849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1907849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1907849 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1907849 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1907849 | pubmed:issn | 0006-2960 | lld:pubmed |
| pubmed-article:1907849 | pubmed:author | pubmed-author:KufeDD | lld:pubmed |
| pubmed-article:1907849 | pubmed:author | pubmed-author:DattaRR | lld:pubmed |
| pubmed-article:1907849 | pubmed:author | pubmed-author:KharbandaSS | lld:pubmed |
| pubmed-article:1907849 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1907849 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:1907849 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:1907849 | pubmed:geneSymbol | c-jun | lld:pubmed |
| pubmed-article:1907849 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1907849 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1907849 | pubmed:pagination | 7947-52 | lld:pubmed |
| pubmed-article:1907849 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:1907849 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1907849 | pubmed:articleTitle | Regulation of c-jun gene expression in HL-60 leukemia cells by 1-beta-D-arabinofuranosylcytosine. Potential involvement of a protein kinase C dependent mechanism. | lld:pubmed |
| pubmed-article:1907849 | pubmed:affiliation | Laboratory of Clinical Pharmacology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115. | lld:pubmed |
| pubmed-article:1907849 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1907849 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1907849 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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