| pubmed-article:1907704 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1907704 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:1907704 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:1907704 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1907704 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:1907704 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:1907704 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:1907704 | lifeskim:mentions | umls-concept:C0229535 | lld:lifeskim |
| pubmed-article:1907704 | lifeskim:mentions | umls-concept:C0733758 | lld:lifeskim |
| pubmed-article:1907704 | lifeskim:mentions | umls-concept:C0023607 | lld:lifeskim |
| pubmed-article:1907704 | lifeskim:mentions | umls-concept:C0032016 | lld:lifeskim |
| pubmed-article:1907704 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1907704 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1907704 | pubmed:dateCreated | 1991-9-10 | lld:pubmed |
| pubmed-article:1907704 | pubmed:abstractText | Interleukin-1 beta (IL-1 beta) at doses of 0.15 and 1.5 nM significantly inhibited FSH secretion and stimulated LH secretion by cultured rat pituitary cells after 24-72 hr incubation whereas 15 pM of IL-1 beta was not effective. Treatment with IL-1 beta for 12-48 hr did not affect intracellular content of FSH. However, treatment with 0.15 and 1.5 nM of IL-1 beta for 72 hr significantly suppressed intracellular content of FSH whereas various doses of IL-1 beta incubated with the cells for 12-72 hr showed no effect on the intracellular content of LH. Pretreatment with IL-1 beta for 48 hr inhibited both GnRH-mediated LH and FSH secretions by the pituitary. The secretion of FSH and LH mediated by an activator of protein kinase C, phorbol 12-myristate 13-acetate, was also significantly suppressed by pretreatment with IL-1 beta for 48 hr. These results suggest that (a) IL-1 beta has opposite effects on the secretion of LH and FSH and (b) pretreatment with IL-1 beta suppresses GnRH-mediated stimulation of LH and FSH by the pituitary and this suppressive effect of IL-1 beta may involve the suppression of a protein kinase C-dependent mechanism. | lld:pubmed |
| pubmed-article:1907704 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1907704 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1907704 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1907704 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1907704 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1907704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1907704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1907704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1907704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1907704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1907704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1907704 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1907704 | pubmed:issn | 0024-3205 | lld:pubmed |
| pubmed-article:1907704 | pubmed:author | pubmed-author:MurataTT | lld:pubmed |
| pubmed-article:1907704 | pubmed:author | pubmed-author:YingS YSY | lld:pubmed |
| pubmed-article:1907704 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1907704 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:1907704 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1907704 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1907704 | pubmed:pagination | 447-53 | lld:pubmed |
| pubmed-article:1907704 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1907704 | pubmed:meshHeading | pubmed-meshheading:1907704-... | lld:pubmed |
| pubmed-article:1907704 | pubmed:meshHeading | pubmed-meshheading:1907704-... | lld:pubmed |
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| pubmed-article:1907704 | pubmed:meshHeading | pubmed-meshheading:1907704-... | lld:pubmed |
| pubmed-article:1907704 | pubmed:meshHeading | pubmed-meshheading:1907704-... | lld:pubmed |
| pubmed-article:1907704 | pubmed:meshHeading | pubmed-meshheading:1907704-... | lld:pubmed |
| pubmed-article:1907704 | pubmed:meshHeading | pubmed-meshheading:1907704-... | lld:pubmed |
| pubmed-article:1907704 | pubmed:meshHeading | pubmed-meshheading:1907704-... | lld:pubmed |
| pubmed-article:1907704 | pubmed:meshHeading | pubmed-meshheading:1907704-... | lld:pubmed |
| pubmed-article:1907704 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1907704 | pubmed:articleTitle | Effects of interleukin-1 beta on secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by cultured rat anterior pituitary cells. | lld:pubmed |
| pubmed-article:1907704 | pubmed:affiliation | Department of Anatomy and Cell Biology, University of Southern California, School of Medicine, Los Angeles 90033. | lld:pubmed |
| pubmed-article:1907704 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1907704 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1907704 | lld:pubmed |
