| pubmed-article:19076926 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19076926 | lifeskim:mentions | umls-concept:C0009170 | lld:lifeskim |
| pubmed-article:19076926 | lifeskim:mentions | umls-concept:C0028040 | lld:lifeskim |
| pubmed-article:19076926 | lifeskim:mentions | umls-concept:C0025611 | lld:lifeskim |
| pubmed-article:19076926 | lifeskim:mentions | umls-concept:C0085208 | lld:lifeskim |
| pubmed-article:19076926 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:19076926 | lifeskim:mentions | umls-concept:C0679080 | lld:lifeskim |
| pubmed-article:19076926 | lifeskim:mentions | umls-concept:C1706204 | lld:lifeskim |
| pubmed-article:19076926 | lifeskim:mentions | umls-concept:C2348519 | lld:lifeskim |
| pubmed-article:19076926 | lifeskim:mentions | umls-concept:C1555721 | lld:lifeskim |
| pubmed-article:19076926 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19076926 | pubmed:dateCreated | 2009-3-17 | lld:pubmed |
| pubmed-article:19076926 | pubmed:abstractText | Bupropion can serve as a discriminative stimulus (S(D)) in an operant drug discrimination task, and a variety of stimulants substitute for the bupropion S(D). There are no reports, however, of bupropion functioning as a Pavlovian occasion setter (i.e. feature positive modulator). The present experiment seeks to fill this gap in the literature by training bupropion in rats as a feature positive modulator that disambiguates when a light will be paired with sucrose. Specifically, on bupropion (10 mg/kg intraperitoneal) sessions, offset of 15-second cue lights were followed by brief delivery of liquid sucrose; saline sessions were similar except no sucrose was available. Rats readily acquired the discrimination with more conditioned responding to the light on bupropion sessions. Bupropion is approved for use as a smoking cessation aid, and more recently has drawn attention as a potential pharmacotherapy for cocaine and methamphetamine abuse. Accordingly, after discrimination training, we tested the ability of cocaine (1-10 mg/kg), methamphetamine (0.1 to 1 mg/kg) and nicotine (0.00625 to 0.2 mg/kg) to substitute for the bupropion feature. Nicotine (0.05 mg/kg) and methamphetamine (0.3 mg/kg) substituted fully for bupropion; cocaine did not substitute. These results extend previous research on shared stimulus properties between bupropion and other stimulants to a Pavlovian occasion setting function. Further, this is the first report of nicotine and methamphetamine substitution for bupropion. The overlap in stimulus properties might explain the effectiveness of bupropion as a smoking cessation aid and highlight the possible utility of bupropion for treatment of stimulant use disorder. | lld:pubmed |
| pubmed-article:19076926 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19076926 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19076926 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19076926 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19076926 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:19076926 | pubmed:issn | 1369-1600 | lld:pubmed |
| pubmed-article:19076926 | pubmed:author | pubmed-author:BevinsRick... | lld:pubmed |
| pubmed-article:19076926 | pubmed:author | pubmed-author:WilkinsonJami... | lld:pubmed |
| pubmed-article:19076926 | pubmed:author | pubmed-author:LiChiaC | lld:pubmed |
| pubmed-article:19076926 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19076926 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:19076926 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19076926 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19076926 | pubmed:pagination | 165-73 | lld:pubmed |
| pubmed-article:19076926 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:19076926 | pubmed:meshHeading | pubmed-meshheading:19076926... | lld:pubmed |
| pubmed-article:19076926 | pubmed:meshHeading | pubmed-meshheading:19076926... | lld:pubmed |
| pubmed-article:19076926 | pubmed:meshHeading | pubmed-meshheading:19076926... | lld:pubmed |
| pubmed-article:19076926 | pubmed:meshHeading | pubmed-meshheading:19076926... | lld:pubmed |
| pubmed-article:19076926 | pubmed:meshHeading | pubmed-meshheading:19076926... | lld:pubmed |
| pubmed-article:19076926 | pubmed:meshHeading | pubmed-meshheading:19076926... | lld:pubmed |
| pubmed-article:19076926 | pubmed:meshHeading | pubmed-meshheading:19076926... | lld:pubmed |
| pubmed-article:19076926 | pubmed:meshHeading | pubmed-meshheading:19076926... | lld:pubmed |
| pubmed-article:19076926 | pubmed:meshHeading | pubmed-meshheading:19076926... | lld:pubmed |
| pubmed-article:19076926 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19076926 | pubmed:articleTitle | Pavlovian drug discrimination with bupropion as a feature positive occasion setter: substitution by methamphetamine and nicotine, but not cocaine. | lld:pubmed |
| pubmed-article:19076926 | pubmed:affiliation | Department of Psychology, University of Nebraska-Lincoln, USA. rbevins1@unl.edu | lld:pubmed |
| pubmed-article:19076926 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19076926 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19076926 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19076926 | lld:pubmed |
