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pubmed-article:19074982pubmed:abstractTextAdiponectin (APM1, ACDC) is an adipocyte-derived protein with downregulated expression in obesity and insulin-resistant states. Several potentially regulatory single nucleotide polymorphisms (SNPs) within the APM1 gene promoter region have been associated with circulating adiponectin levels. None of them have been functionally characterized in adiponectin-expressing cells. Hence, we investigated three SNPs (rs16861194, rs17300539, and rs266729) for their influence on adiponectin promoter activity and their association with circulating adiponectin levels.lld:pubmed
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pubmed-article:19074982pubmed:articleTitleFunctional characterization of promoter variants of the adiponectin gene complemented by epidemiological data.lld:pubmed
pubmed-article:19074982pubmed:affiliationElse Kröner-Fresenius-Center for Nutritional Medicine, Technische Universität München, Munich, Germany. helmut.laumen@wzw.tum.delld:pubmed
pubmed-article:19074982pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19074982pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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